Evidence map›Paper›PMID 40072684›Full record

ReviewAMB Express2025

Recent insights on phage therapy against multidrug-resistant Acinetobacter baumannii.

Ann A Elshamy, Sandra K Kamal, Mariam T Mahmoud, Aya M Elhasany, Aya A Shady, Sherok A Mohamed, Hasna A Abd-Elmaaboud, Nour E El-Awady, Rana A Mohamed, Sara A El-Mirghany and 3 more

Abstract readReview
In one paragraph

Review in AMB Express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
  5. Article
  6. Review
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  8. Review
  9. Identification of multi-drug resistantFrontiers in microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ann A ElshamyDepartment of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Sandra K KamalFaculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Mariam T MahmoudFaculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Aya M ElhasanyFaculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Aya A ShadyFaculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Sherok A MohamedFaculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Hasna A Abd-ElmaaboudFaculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Nour E El-AwadyFaculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Rana A MohamedFaculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Sara A El-MirghanyFaculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Sarraa W El-HadyFaculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Mohamed M Abd-ElRahmanFaculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Khaled M AboshanabDepartment of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt. aboshanab2012@pharma.asu.edu.eg.ORCID http://orcid.org/0000-0002-7608-850X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acinetobacter baumannii is a prevalent clinical pathogen commonly found to be multidrug-resistant (MDR), causing serious to life-threatening infections, particularly hospital-acquired infections with limited therapeutic options. The MDR phenotype developed against this critical pathogen is increasingly developed globally, reaching a pan-drug-resistant phenotype conferring non-susceptibility to all antimicrobials used in its treatment according to the standard guidelines. Therefore, it is critical to develop innovative treatment approaches, such as phage therapy, considering the rise in drug-resistant A. baumannii infections. In this review, we highlight and discuss the up-to-date antimicrobial resistance of A. baumannii, the use of phages, their limitations, and future perspectives in treating A. baumannii infections. In addition, the combination of phages with antimicrobials, preclinical and clinical studies including pharmacokinetics and pharmacodynamics properties have been discussed.

Indexed as

Acinetobacter baumanniiAntimicrobial resistanceMultidrug resistancePhage cocktailPhage therapy

Identifiers

PMID40072684
PMCPMC11904003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.