Evidence map›Paper›PMID 40072660›Full record

ArticleEuropean journal of nutrition2025

Dietary risk factors in Crohn's disease and ulcerative colitis: a cohort study with paired healthy relatives as controls.

Jun Hu, Wanning Chen, Ruixin Zhu, Fang Yang, Jinhong Xu, Bingjie Xiang, Yichen Li, Wenxia Wang, Lixin Zhu, Guoxun Chen and 1 more

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In one paragraph

Article in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jun HuGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Biomedical Innovation Center, The Sixth Affiliated Hospital, Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Guangdong Institute of Gastroenterology, Sun Yat-sen University, Ministry of Education, Guangzhou, 510655, P. R. China.
Wanning ChenDepartment of Gastroenterology, The Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200072, P. R. China.
Ruixin ZhuDepartment of Gastroenterology, The Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200072, P. R. China. rxzhu@tongji.edu.cn.
Fang YangSchool of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, 430065, P. R. China.
Jinhong XuCollege of Food Science and Technology, College of Biomedicine and Health, Huazhong Agricultural University, Wuhan, 430070, P. R. China.
Bingjie XiangGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Biomedical Innovation Center, The Sixth Affiliated Hospital, Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Guangdong Institute of Gastroenterology, Sun Yat-sen University, Ministry of Education, Guangzhou, 510655, P. R. China.
Yichen LiGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Biomedical Innovation Center, The Sixth Affiliated Hospital, Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Guangdong Institute of Gastroenterology, Sun Yat-sen University, Ministry of Education, Guangzhou, 510655, P. R. China.
Wenxia WangDepartment of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, P. R. China.
Lixin ZhuGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Biomedical Innovation Center, The Sixth Affiliated Hospital, Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Guangdong Institute of Gastroenterology, Sun Yat-sen University, Ministry of Education, Guangzhou, 510655, P. R. China. zzllxx2000@gmail.com.ORCID http://orcid.org/0000-0001-7904-1769
Guoxun ChenCollege of Food Science and Technology, College of Biomedicine and Health, Huazhong Agricultural University, Wuhan, 430070, P. R. China. guoxun.chen@mail.hzau.edu.cn.
Min ZhiGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Biomedical Innovation Center, The Sixth Affiliated Hospital, Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Guangdong Institute of Gastroenterology, Sun Yat-sen University, Ministry of Education, Guangzhou, 510655, P. R. China. zhimin@mail.sysu.edu.cn.

Funding

Guangdong Province "Pearl River Talent Plan" Innovation and Entrepreneurship Team Project 2019ZT08Y464Hubei Provincial Natural Science Foundation of China 2023AFD124National Key Research and Development Program of China 2021YFF0703702National Key Research and Development Program of China 2023YFF1104404National Natural Science Foundation of China 82170542National Natural Science Foundation of China 82270544National Natural Science Foundation of China 92251307Sun Yat-sen University Clinical Research 5010 Program 2014008
6 · The paper itself

Abstract

purposeConflicting results have been reported on dietary factors in inflammatory bowel diseases (IBDs). Here, we compared the dietary intakes of IBD patients with those of paired healthy relatives (HRs), aiming to minimize the impact of genetic and environmental confounders.

methodsPatients with Crohn's disease (CD, N = 45) and ulcerative colitis (UC, N = 20), their paired HRs (N

resultsDietary features identified in IBD patients using the HR controls differed from those identified using the HNR controls. For CD, lower intakes of vitamin C, dietary fiber, calcium, vegetables, decanoic acid (10:0), milk, dairy foods, and β-carotene were identified as risk factors when compared to HRs. LASSO regression highlighted milk, vegetables, and vitamin C as the most significant risk factors for CD. In UC patients, lower intakes of phosphorus, docosapentaenoic acid (DPA, 22:5, n-3), vitamins B-2 and B-12, and choline, along with a higher intake of α-carotene, were identified as risk factors compared to HRs. LASSO regression emphasized DPA, vitamins B-2 and B-12, and α-carotene as the most significant risk factors for UC.

conclusionMonitoring dietary intake patterns is crucial for the prevention and personalized treatment of CD and UC.

Indexed as

Colitis, UlcerativeCrohn DiseaseDietAdultCase-Control StudiesCohort StudiesFamilyFemaleHumansMaleMiddle AgedRisk FactorsDPAMilkVegetableVitamin AVitamin B-12Vitamin B-2Vitamin C

Identifiers

PMID40072660

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.