ArticleOral and maxillofacial surgery2025
Fabrication of porous collagen-stem cells-dexamethasone scaffold as a novel approach for regeneration of mandibular bone defect.
Article in Oral and maxillofacial surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Mastoid Obliteration After Canal Wall Down Mastoidectomy Using Tissue Engineering Approaches with Polymers, Mesenchymal Stem Cells, and Bioactive Molecules: A Systematic Review.Bioengineering (Basel, Switzerland) · 2026Review
- Advances in Composite Bioactive Scaffolds for Alveolar Bone Repair: Implications for Oral Surgery.Brazilian dental journal · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundBone defects, particularly in the mandible, pose significant clinical challenges due to the limited regenerative capacity. Effective bone tissue engineering requires biomaterials that promote both osteogenesis and angiogenesis. This study developed an optimized collagen-nano hydroxyapatite scaffold loaded with dexamethasone and stem cells to enhance bone regeneration.
methodsThe scaffold was fabricated using the freeze-dryer method. Characterization was performed using Fourier Transform Infrared Spectroscopy (FTIR), energy-dispersive X-ray (EDX) analysis, and scanning electron microscopy (SEM). Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) were incorporated into the scaffold, and in vitro and in vivo assessments were conducted.
resultsFTIR and EDX analyses confirmed the successful incorporation of nano-hydroxyapatite and dexamethasone. SEM revealed an interconnected porous structure with an average pore size of 28.55 µm. The scaffold loaded with WJ-MSCs significantly enhanced osteocyte and osteoblast populations, leading to improved mandibular bone formation. Histopathological evaluations demonstrated superior osteogenesis and angiogenesis.
conclusionThe developed porous nanohybrid scaffold shows potential as a promising biomaterial for bone tissue engineering applications.
Indexed as
Identifiers
40072639What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.