Evidence map›Paper›PMID 40072633›Full record

ArticleArchives of dermatological research2025

Overexpression of lncRNA TINCR inhibits cutaneous squamous cell carcinoma cells through promotes methylation of Myc and TERC genes.

Liang Wang, Yu Wang, Lei Xu

Abstract read
PubMed Full text at PMC Publisher
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Article in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

3 authors.

Liang WangDepartment of Dermatology, The First Affiliated Hospital of Harbin Medical University, 23 Post Street, Nangang District, Harbin, Heilongjiang, 150001, China. wangliangk5678@163.com.
Yu WangDepartment of Dermatology, The First Affiliated Hospital of Harbin Medical University, 23 Post Street, Nangang District, Harbin, Heilongjiang, 150001, China.
Lei XuDepartment of Dermatology, The First Affiliated Hospital of Harbin Medical University, 23 Post Street, Nangang District, Harbin, Heilongjiang, 150001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNA (lncRNA) TINCR has been shown to play a crucial regulatory role in various tumors. However, its specific mechanism of action in cutaneous squamous cell carcinoma (CSCC) remains unclear. This study aimed to explore the role of lncRNA TINCR in CSCC. We utilized overexpression techniques to study the effects of TINCR on CSCC cells. Methylation-specific PCR (MSP) and RNA immunoprecipitation (RIP) assays were used to assess the impact of TINCR on the methylation of the promoter regions of the Myc and TERC genes, and its interaction with DNA methyltransferase 1 (DNMT1). The results showed that overexpression of TINCR significantly promoted methylation in the promoter regions of Myc (N-MYC, L-MYC, and c-MYC) and TERC genes, inhibiting the proliferation, migration, and invasion of CSCC cells. MSP and RIP experiments further confirmed that TINCR binds to DNMT1, enhancing the methylation levels of the promoter regions of Myc and TERC genes. These findings suggest that lncRNA TINCR may serve as a potential therapeutic target for CSCC by regulating the methylation of key oncogenes. These findings provide new insights into the molecular mechanisms of CSCC and highlight the therapeutic potential of targeting TINCR.

Indexed as

Carcinoma, Squamous CellProto-Oncogene Proteins c-mycRNARNA, Long NoncodingSkin NeoplasmsTelomeraseCell Line, TumorCell MovementCell ProliferationDNA (Cytosine-5-)-Methyltransferase 1DNA MethylationGene Expression Regulation, NeoplasticHumansPromoter Regions, GeneticDNA (Cytosine-5-)-Methyltransferase 1DNMT1 protein, humanMYC protein, humanProto-Oncogene Proteins c-mycRNARNA, Long NoncodingTelomerasetelomerase RNATINCR lncRNA, humanCell migrationCell proliferationCutaneous squamous cell carcinomaLong non-coding RNAMethylation

Identifiers

PMID40072633
PMCPMC11903621

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