Evidence map›Paper›PMID 40072620›Full record

ArticleJournal of neurology2025

Contribution of fatigue experienced by Parkinson's Disease patients on caregiver burden.

Salvatore Landolfo, Daniele Urso, Carlo Santoro, Lucia Batzu, Valentina Gnoni, Alessia Giugno, Silvia Rota, Davide Vilella, Fabio Amati, Karolina Popławska-Domaszewicz and 3 more

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In one paragraph

Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Salvatore Landolfo *Department of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari 'Aldo Moro', "Pia Fondazione Cardinale G. Panico", Via San Pio X, 73039, Tricase, Lecce, Italy.ORCID http://orcid.org/0009-0008-0448-4272
Daniele Urso *Department of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari 'Aldo Moro', "Pia Fondazione Cardinale G. Panico", Via San Pio X, 73039, Tricase, Lecce, Italy. danieleurso010@gmail.com.ORCID http://orcid.org/0000-0002-4503-0110
Carlo SantoroDepartment of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari 'Aldo Moro', "Pia Fondazione Cardinale G. Panico", Via San Pio X, 73039, Tricase, Lecce, Italy.
Lucia BatzuDepartment of Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, UK.
Valentina GnoniDepartment of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari 'Aldo Moro', "Pia Fondazione Cardinale G. Panico", Via San Pio X, 73039, Tricase, Lecce, Italy.
Alessia GiugnoDepartment of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari 'Aldo Moro', "Pia Fondazione Cardinale G. Panico", Via San Pio X, 73039, Tricase, Lecce, Italy.
Silvia RotaDepartment of Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, UK.
Davide VilellaDepartment of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari 'Aldo Moro', "Pia Fondazione Cardinale G. Panico", Via San Pio X, 73039, Tricase, Lecce, Italy.
Fabio AmatiDepartment of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari 'Aldo Moro', "Pia Fondazione Cardinale G. Panico", Via San Pio X, 73039, Tricase, Lecce, Italy.
Karolina Popławska-DomaszewiczDepartment of Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, UK.
Stefano Giannoni-LuzaDepartment of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari 'Aldo Moro', "Pia Fondazione Cardinale G. Panico", Via San Pio X, 73039, Tricase, Lecce, Italy.
K Ray ChaudhuriDepartment of Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, UK.
Giancarlo LogroscinoDepartment of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari 'Aldo Moro', "Pia Fondazione Cardinale G. Panico", Via San Pio X, 73039, Tricase, Lecce, Italy.

Funding

Regione Puglia and CNR for Tecnopolo per la Medicina di Precisione B84I18000540002
6 · The paper itself

Abstract

backgroundFatigue is a common non-motor symptom (NMS) in Parkinson's disease (PD), affecting up to 50% of patients. It is suggested that PD-related fatigue may contribute to the burden perceived by caregivers.

objectiveThis study aims to evaluate the impact of PD-related fatigue on caregiver burden.

methodsData were obtained from PD patients and their primary caregivers recruited at the Centre for Neurodegenerative Diseases and the Aging Brain, Tricase (Italy), as part of the Non-motor International Longitudinal Study (NILS). Fatigue was assessed using the Fatigue Severity Scale (FSS), while the Caregiver Burden Inventory (CBI) was completed by carers. Univariate and multivariable regression models were employed to assess the relationship of patients' characteristics and non-motor symptoms with caregiver burden.

resultsA total of 61 patients were included. Univariate analysis showed disease duration, NMS burden, depression, cognitive performance, and FSS score as potential clinical predictors of CBI. After multivariable analysis, only FSS score and disease duration remained significantly associated with caregiver burden.

conclusionPatients' fatigue significantly impacts caregivers in PD. Our study fills the gap in the literature exploring this association and emphasizing fatigue assessment to improve the well-being of both individuals with PD and caregivers.

Indexed as

CaregiversCost of IllnessFatigueParkinson DiseaseAgedFemaleHumansLongitudinal StudiesMaleMiddle AgedSeverity of Illness IndexBurdenCaregiverFatigueParkinson’s disease

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.