ArticleArchives of dermatological research2025
Tangeretin regulates oxidative stress in cutaneous melanoma cells via the Nrf2 signaling pathway.
Article in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Onconase Induces Apoptosis in Dabrafenib-Resistant Melanoma Cell Lines Through Dysregulation of ROS Homeostasis, Antioxidant Protein Expression, and Mitochondrial Dynamics.International journal of molecular sciences · 2026Article
- The Influence of Dietary Factors on Melanoma Development and Progression: A Comprehensive Review.Nutrients · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress is a key factor in melanoma progression, making it an important therapeutic target. This study explored the effects of tangeretin, a citrus-derived flavonoid, on human melanoma A375 cells and its underlying mechanisms. A375 cells were treated with tangeretin at various concentrations. The effects of tangeretin on cell proliferation, migration, invasion, and apoptosis were assessed using MTT, wound healing, Transwell invasion, and flow cytometry assays, respectively. Oxidative stress markers, including reactive oxygen species (ROS), malondialdehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD), were evaluated. Western blot was used to measure the expression levels of key proteins in the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway and apoptosis-related markers. The results showed that tangeretin significantly inhibited cell proliferation in a dose-dependent manner, induced apoptosis by increasing the Bax/Bcl-2 ratio, and suppressed cell migration and invasion. Additionally, tangeretin reduced oxidative stress by decreasing ROS and MDA levels while enhancing GSH content and SOD activity. Mechanistically, tangeretin activated the Nrf2 signaling pathway, increasing the expression of Nrf2 and its downstream antioxidant proteins heme oxygenase-1, quinone oxidoreductase 1, and γ-Glutamylcysteine synthetase. These findings suggest that tangeretin exerts anti-cancer effects on melanoma cells by regulating oxidative stress, inhibiting proliferation and metastasis, and inducing apoptosis via the Nrf2 pathway. Tangeretin may serve as a promising candidate for melanoma treatment.
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Registered trials
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