Evidence map›Paper›PMID 40072596›Full record

ArticleJournal of neurology2025

Clinical characterization of diseases associated with anti-N-methyl-D-aspartate receptor encephalitis combined with anti-myelin oligodendrocyte glycoprotein antibodies in adults.

Yingyue Ding, Dalong Wu, Hongshan Chu, Yuqi Tang, Liang Liu, Zhandong Qiu, Zheng Liu, Huirong Yang, Huiqing Dong, Dawei Li

Abstract read
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Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yingyue DingDepartment of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China.
Dalong WuDepartment of Encephalopathy, The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, Jilin, China.
Hongshan ChuDepartment of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China.
Yuqi TangDepartment of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China.
Liang LiuDepartment of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China.
Zhandong QiuDepartment of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China.
Zheng LiuDepartment of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China.
Huirong YangSchool of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China.
Huiqing DongDepartment of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China.
Dawei LiDepartment of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China. davidl163@163.com.ORCID http://orcid.org/0000-0003-3696-658X

Funding

Beijing Municipal Administration of Hospitals Incubating Program PX2025028Jilin Province Traditional Chinese Medicine Science and Technology Project 2024022The Jilin Province Hygiene and Health Science and Technology Capacity Enhancement Project 2022JC046
6 · The paper itself

Abstract

objectiveThe aim of this study was to analyze the clinical characteristics of adult patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis combined with anti-myelin oligodendrocyte glycoprotein (MOG) antibodies.

methodsThis was a non-randomized controlled study. Clinical data were collected from 17 patients with anti-NMDAR encephalitis combined with anti-MOG antibodies admitted to Xuanwu Hospital, Capital Medical University, from January 2020 to August 2024. As controls, 20 patients with NMDAR(+)/MOG(-) and 27 patients with MOG(+)/NMDAR(-) were selected.

resultsThe mean age of onset in the double-positive group was 33.47 ± 1.065 years, with a male-to-female ratio of 14:3. Significant differences were observed between the NMDAR(+)/MOG(+) group and the NMDAR(+)/MOG(-) group in terms of headache, lumbar puncture pressure, and cerebrospinal fluid (CSF) leukocyte counts (P < 0.05). Comparing the NMDAR(+)/MOG(+) group with the MOG(+)/NMDAR(-) group revealed significant differences in gender, headache, mental and behavioral abnormalities, limb twitching, loss of consciousness, cognitive impairment, speech impairment, visual impairment, limb numbness, cortical/sub-cortical white matter, brainstem lesions, OB type II, and CSF leukocyte counts (P < 0.05). No statistically significant differences were found in the comparison of CSF and serum antibody titers among the three groups (P > 0.05).

conclusionNMDAR and MOG antibodies can coexist in patients with autoimmune diseases, with a predominance of young male patients. The double-positive group exhibited more severe intracranial viral infections and a higher rate of intrathecal immunoglobulin synthesis in the central tissues. Compared to the double-positive group, NMDAR encephalitis alone presented with more similar clinical manifestations, while MOG-related disease demonstrated a higher likelihood of brainstem involvement.

Indexed as

Anti-N-Methyl-D-Aspartate Receptor EncephalitisAutoantibodiesMyelin-Oligodendrocyte GlycoproteinAdultFemaleHumansMaleMiddle AgedReceptors, N-Methyl-D-AspartateYoung AdultAutoantibodiesMOG protein, humanMyelin-Oligodendrocyte GlycoproteinReceptors, N-Methyl-D-AspartateAnti-MOG antibodyAnti-NMDAR encephalitisDemyelinating disease

Identifiers

PMID40072596

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