Evidence map›Paper›PMID 40072585›Full record

SynthesisRheumatology international2025

Characteristics and factors associated with treatment response among patients with eosinophilic fasciitis: a systematic review and meta-analysis.

Omar Hamdan, Roa'a Alshajrawi, Qais Mussa, Yazeed Alajlouni, Yazan Dabbah, Rawan Fratekh, Yousef Al-Mabrouk, Shatha Al-Mabrok, Ahmad A Toubasi, Fatima Alnaimat

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Rheumatology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. [Eosinophilic fascitis: A case report and literature review].Revista medica del Instituto Mexicano del Seguro Social · 2026
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Omar HamdanSchool of Medicine, University of Jordan, Amman, 19942, Jordan.ORCID 0009-0008-0442-0578
Roa'a AlshajrawiSchool of Medicine, University of Jordan, Amman, 19942, Jordan.ORCID 0000-0003-3619-7645
Qais MussaSchool of Medicine, University of Jordan, Amman, 19942, Jordan.ORCID 0009-0006-7350-6143
Yazeed AlajlouniSchool of Medicine, University of Jordan, Amman, 19942, Jordan.ORCID 0009-0004-1079-5633
Yazan DabbahSchool of Medicine, University of Jordan, Amman, 19942, Jordan.ORCID 0009-0000-1958-4796
Rawan FratekhSchool of Medicine, University of Jordan, Amman, 19942, Jordan.ORCID 0009-0005-6371-4750
Yousef Al-MabroukSchool of Medicine, Mansoura University, Almansoura, 35516, Egypt.ORCID 0009-0007-8045-2048
Shatha Al-MabrokSchool of Medicine, Mansoura University, Almansoura, 35516, Egypt.ORCID 0009-0009-6231-368X
Ahmad A ToubasiSchool of Medicine, University of Jordan, Amman, 19942, Jordan.ORCID 0000-0002-4688-9728
Fatima AlnaimatDepartment of Internal Medicine, Division of Rheumatology, School of Medicine, University of Jordan, Amman, 11942, Jordan. f.naimat@ju.edu.jo.ORCID 0000-0002-5574-2939

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesEosinophilic Fasciitis (EF) is a rare connective tissue disorder characterized by skin thickening. Few studies explored its characteristics and factors associated with treatment response.

methodsPubMed, CENTRAL, Web of Sciences, and Scopus databases were searched in July 2023 to identify all published case reports of EF without restrictions on publication year or language. We extracted patients' demographics, clinical symptoms, laboratory findings, biopsy results and treatment outcomes.

resultsWe analyzed 476 published case reports with an aggregate number of 597 patients. The mean age of the patients was 44.52, with a 1:1 male-to-female ratio. Comorbid autoimmune diseases were present in 13.3% of patients. The most common reported skin manifestation was induration (80.7%), with the most commonly affected body part being the legs (77.1%). Only 1.6% of patients had Raynaud's phenomena and 3.1% of patients had Dysphagia. Hypereosinophilia was present in 90.2% and hypergammaglobulinemia was present in 65.9%. Corticosteroids were received by 89.7% of patients. The majority of patients (82.2%) exhibited a clinical response to treatment, but 24.5% of patients who initially responded to treatment relapsed. Patients who received oral corticosteroid monotherapy were significantly more likely to respond to treatment compared to those who received other treatments (56.2% Vs. 39.4%). Patients who had forearm skin involvement (OR = 3.459; 95% CI: 1.334-8.966) had significantly higher odds of clinical response to treatment.

conclusionsEF is a complex disease with non-specific symptoms. Our study offers comprehensive insights into patient characteristics and treatment outcomes, aiding clinicians in enhancing their approach.

Indexed as

Adrenal Cortex HormonesEosinophiliaFasciitisFemaleHumansMaleTreatment OutcomeAdrenal Cortex HormonesEosinophilic fasciitisFasciitisFasciitis with diffuse eosinophiliaShulman’s diseaseShulman syndrome

Identifiers

PMID40072585

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.