Evidence map›Paper›PMID 40072511›Full record

ArticleMolecular biology of the cell2025

Relationship between time-dependent epidermal ceramide composition changes and skin barrier function in adult mice.

Taiga Hiranuma, Takayuki Sassa, Akio Kihara

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Discovery of Dihydroxy-Ketone-Type Protein-Bound Ceramides as the Dominant Type in Human Stratum Corneum.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Taiga HiranumaLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12-jo, Nishi 6-chome, Kita-ku, Sapporo 060-0812, Japan.
Takayuki SassaLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12-jo, Nishi 6-chome, Kita-ku, Sapporo 060-0812, Japan.
Akio KiharaLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12-jo, Nishi 6-chome, Kita-ku, Sapporo 060-0812, Japan.ORCID 0000-0001-5889-0788

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ceramides, especially acylceramides and protein-bound ceramides, are important for skin barrier formation. However, due to the neonatal lethality of knockout (KO) of the genes involved in the production of these ceramides, the effects of their KO in adult mice have been unclear. To investigate these effects, we created mice with tamoxifen-inducible conditional KO of the fatty acid elongase

Indexed as

CeramidesEpidermisAcetyltransferasesAnimalsCell DifferentiationCell ProliferationFatty Acid ElongasesKeratinocytesLipid MetabolismMiceMice, KnockoutSkinAcetyltransferasesCeramidesFatty Acid Elongases

Identifiers

PMID40072511
PMCPMC12086569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.