ArticleEpilepsia2025
Prognostic value of interictal epileptiform discharges on routine EEG in adults with epilepsy.
Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Association between Interictal Spike Rate and Seizure Frequency in a Large Epilepsy Cohort.medRxiv : the preprint server for health sciences · 2026Article
- Network reprogramming after resection of occipital meningioangiomatosis: Evidence from multimodal localization and longitudinal fMRI.Epilepsy & behavior reports · 2026Article
- Development and validation of a deep survival model to predict time to seizure from routine electroencephalography.Epilepsia · 2026Article
- Artificial intelligence for automated detection of interictal epileptiform discharges: methodological progress, clinical evaluation, and neurodevelopmental context.Frontiers in cell and developmental biology · 2026Review
- Not All Spikes Are Equal.Journal of clinical medicine · 2025Review
- Prognostic value of interictal epileptiform discharges on routine EEG in adults with epilepsy.Epilepsia · 2025Article
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Authors and funding
7 authors.
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Abstract
objectiveTo determine whether interictal epileptiform discharges (IEDs) on routine electroencephalography (EEG) predict seizure recurrence in adults with established epilepsy.
methodsWe conducted a retrospective survival analysis of consecutive adults with epilepsy undergoing routine EEG at a tertiary center between 2018 and 2019. Using multivariate Cox proportional hazards models guided by a directed acyclic graph and adjusted for confounders including past seizure frequency and duration of epilepsy, we estimated the association between the presence of IEDs and time to next seizure, stratified by epilepsy type.
resultsWe included 488 consecutive routine EEG studies from 438 patients. Over a median follow-up of 124.5 weeks, seizures recurred in 50.4% of cases. The presence of IEDs was associated with increased seizure risk in both focal (adjusted hazard ratio [aHR] = 1.47, 95% confidence interval [CI]: 1.01-2.15, p = .043) and generalized epilepsy (aHR = 1.82, 95% CI: 1.08-3.06, p = .024). SIGNIFICANCE: IEDs on routine EEG independently predict increased seizure risk in adults with epilepsy, with a stronger effect in generalized epilepsies. This suggests that routine EEG may have prognostic value during epilepsy follow-up and warrant further investigations as a potential prognostic biomarker to help inform clinical decision-making.
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