Evidence map›Paper›PMID 40072351›Full record

ArticleCancer science2025

Targeting RNA Polymerase I in Ewing Sarcoma Treatment.

Alexis Bruce, Gavin Anchondo, Rebekah Carter, Sergio Guerrero Pacheco, Hema Sri Kambala, Elizabeth Cortez, Kyra Parker, Le Su

Abstract readLetter
In one paragraph

Article in Cancer science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexis BruceDepartment of Biology, Jacksonville State University, Jacksonville, Alabama, USA.
Gavin AnchondoDepartment of Biology, Jacksonville State University, Jacksonville, Alabama, USA.
Rebekah CarterDepartment of Biology, Jacksonville State University, Jacksonville, Alabama, USA.
Sergio Guerrero PachecoDepartment of Biology, Jacksonville State University, Jacksonville, Alabama, USA.
Hema Sri KambalaDepartment of Biology, Jacksonville State University, Jacksonville, Alabama, USA.
Elizabeth CortezDepartment of Biology, Jacksonville State University, Jacksonville, Alabama, USA.
Kyra ParkerDepartment of Biology, Jacksonville State University, Jacksonville, Alabama, USA.
Le SuDepartment of Biology, Jacksonville State University, Jacksonville, Alabama, USA.ORCID https://orcid.org/0009-0005-5434-775X

Funding

St. Baldrick's Foundation
6 · The paper itself

Abstract

Pharmacologic inhibition of RNA polymerase I activity represents a new therapeutic approach for Ewing sarcoma. This is the first time key components of the ribosome biogenesis pathway have been linked to Ewing sarcoma biology.

Indexed as

Antineoplastic AgentsBone NeoplasmsEnzyme InhibitorsRNA Polymerase ISarcoma, EwingHumansMolecular Targeted TherapyRibosomesAntineoplastic AgentsEnzyme InhibitorsRNA Polymerase I

Identifiers

PMID40072351
PMCPMC12317381

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.