Evidence map›Paper›PMID 40072095›Full record

ArticleCells2025

Exploring Metabolic Shifts in Kidney Cancer and Non-Cancer Cells Under Pro- and Anti-Apoptotic Treatments Using NMR Metabolomics.

Lucia Trisolini, Biagia Musio, Beatriz Teixeira, Maria Noemi Sgobba, Anna Lucia Francavilla, Mariateresa Volpicella, Lorenzo Guerra, Anna De Grassi, Vito Gallo, Iola F Duarte and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lucia TrisoliniDepartment of Biosciences, Biotechnologies and Environment, University of Bari "Aldo Moro", Via Orabona, 4, 70125 Bari, Italy.
Biagia MusioDepartment of Civil, Environmental, Land, Building Engineering and Chemistry (DICATECh), Polytechnic University of Bari, Via Orabona, 4, 70125 Bari, Italy.ORCID 0000-0001-7799-5155
Beatriz TeixeiraCICECO-Aveiro Institute of Materials and LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0009-0007-0869-3568
Maria Noemi SgobbaDepartment of Biosciences, Biotechnologies and Environment, University of Bari "Aldo Moro", Via Orabona, 4, 70125 Bari, Italy.ORCID 0000-0002-6916-325X
Anna Lucia FrancavillaDepartment of Biosciences, Biotechnologies and Environment, University of Bari "Aldo Moro", Via Orabona, 4, 70125 Bari, Italy.ORCID 0009-0006-8947-9733
Mariateresa VolpicellaDepartment of Biosciences, Biotechnologies and Environment, University of Bari "Aldo Moro", Via Orabona, 4, 70125 Bari, Italy.ORCID 0000-0002-8047-3881
Lorenzo GuerraDepartment of Biosciences, Biotechnologies and Environment, University of Bari "Aldo Moro", Via Orabona, 4, 70125 Bari, Italy.ORCID 0000-0003-3950-9405
Anna De GrassiDepartment of Biosciences, Biotechnologies and Environment, University of Bari "Aldo Moro", Via Orabona, 4, 70125 Bari, Italy.ORCID 0000-0001-7273-4263
Vito GalloDepartment of Civil, Environmental, Land, Building Engineering and Chemistry (DICATECh), Polytechnic University of Bari, Via Orabona, 4, 70125 Bari, Italy.ORCID 0000-0003-2926-3106
Iola F DuarteCICECO-Aveiro Institute of Materials and LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0003-4289-9256
Ciro Leonardo PierriDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari "Aldo Moro", Via Orabona, 4, 70125 Bari, Italy.ORCID 0000-0003-1816-548X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigates the metabolic responses of cancerous (RCC) and non-cancerous (HK2) kidney cells to treatment with Staurosporine (STAU), which has a pro-apoptotic effect, and Bongkrekic acid (BKA), which has an anti-apoptotic effect, individually and in combination, using

Indexed as

ApoptosisKidney NeoplasmsMetabolomicsCell Line, TumorHumansMagnetic Resonance SpectroscopyMetabolomeMitochondriaStaurosporineStaurosporineapoptosisBongkrekic acidkidney cell linesmitochondriaNMR metabolomicsStaurosporine

Identifiers

PMID40072095
PMCPMC11899725

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.