Evidence map›Paper›PMID 40072089›Full record

ArticleCells2025

Skim Milk Culture of

Michio Kawano, Toshinobu Arai, Toshihide Kabuki

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michio KawanoMilk Science Research Institute, MEGMILK SNOW BRAND Co., Ltd., 1-1-2 Minamidai, Kawagoe-shi, Saitama 350-1165, Japan.
Toshinobu AraiMilk Science Research Institute, MEGMILK SNOW BRAND Co., Ltd., 1-1-2 Minamidai, Kawagoe-shi, Saitama 350-1165, Japan.
Toshihide KabukiMilk Science Research Institute, MEGMILK SNOW BRAND Co., Ltd., 1-1-2 Minamidai, Kawagoe-shi, Saitama 350-1165, Japan.

Funding

Megmilk Snow Brand (Japan) None
6 · The paper itself

Abstract

BACKGROUND/

objectivesIntestinal alkaline phosphatase (IAP) is an enzyme expressed in the intestinal brush border, which may exert anti-inflammatory effects by detoxifying lipopolysaccharides (LPSs), thereby preventing metabolic disorders. Various food components have been reported to influence IAP activity. However, few studies have evaluated the effects of fermented milk on IAP activity. In this study, we aimed to investigate fermented milk with high IAP-activating capacity and investigate its effect.

methodsWe screened a skim milk culture (SC), a fermented milk model, using differentiated Caco-2 cells. We investigated the effect of SC on IAP activity and gene expression in the

resultsAmong the SC samples from different lactic acid bacteria or bifidobacteria, the SC of

conclusionsLJ0309 SC increased IAP activity and gene expression in both Caco-2 cells and the

Indexed as

Alkaline PhosphataseEpithelial CellsInterleukin-8Intestinal MucosaIntestinesLactobacillus johnsoniiLipopolysaccharidesMilkAnimalsCaco-2 CellsDrosophila melanogasterHumansAlkaline PhosphataseInterleukin-8LipopolysaccharidesCaco-2 cellsDrosophila melanogasterfermented milkintestinal alkaline phosphataseLactobacillus johnsonii SBT0309lipopolysaccharideskim milk culture

Identifiers

PMID40072089
PMCPMC11898809

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.