Evidence map›Paper›PMID 40072087›Full record

ArticleCells2025

The Evolutionary Young Actin Nucleator Cobl Is Important for Proper Amelogenesis.

Hannes Janitzek, Jule González Delgado, Natja Haag, Eric Seemann, Sandor Nietzsche, Bernd Sigusch, Britta Qualmann, Michael Manfred Kessels

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hannes JanitzekInstitute of Biochemistry I, Jena University Hospital-Friedrich Schiller University Jena, Nonnenplan 2-4, 07743 Jena, Germany.
Jule González DelgadoInstitute of Biochemistry I, Jena University Hospital-Friedrich Schiller University Jena, Nonnenplan 2-4, 07743 Jena, Germany.
Natja HaagInstitute of Biochemistry I, Jena University Hospital-Friedrich Schiller University Jena, Nonnenplan 2-4, 07743 Jena, Germany.
Eric SeemannInstitute of Biochemistry I, Jena University Hospital-Friedrich Schiller University Jena, Nonnenplan 2-4, 07743 Jena, Germany.ORCID 0000-0002-3270-1253
Sandor NietzscheCenter for Electron Microscopy, Jena University Hospital-Friedrich Schiller University Jena, Ziegelmühlenweg 1, 07743 Jena, Germany.
Bernd SiguschDepartment of Conservative Dentistry and Periodontology, Jena University Hospital-Friedrich Schiller University Jena, An der alten Post 4, 07743 Jena, Germany.
Britta QualmannInstitute of Biochemistry I, Jena University Hospital-Friedrich Schiller University Jena, Nonnenplan 2-4, 07743 Jena, Germany.ORCID 0000-0002-5743-5764
Michael Manfred KesselsInstitute of Biochemistry I, Jena University Hospital-Friedrich Schiller University Jena, Nonnenplan 2-4, 07743 Jena, Germany.ORCID 0000-0001-5967-0744

Funding

Deutsche Forschungsgemeinschaft KE685/7-1Deutsche Forschungsgemeinschaft QU116/10-1
6 · The paper itself

Abstract

The actin cytoskeleton plays an important role in morphological changes of ameloblasts during the formation of enamel, which is indispensable for teeth to withstand wear, fracture and caries progression. This study reveals that the actin nucleator Cobl is expressed in ameloblasts of mandibular molars during amelogenesis. Cobl expression was particularly pronounced during the secretory phase of the enamel-forming cells. Cobl colocalized with actin filaments at the cell cortex. Importantly, our analyses show an influence of Cobl on both ameloblast morphology and cytoskeletal organization as well as on enamel composition. At P0,

Indexed as

AmelogenesisActin CytoskeletonActinsAmeloblastsAnimalsDental EnamelMiceMice, KnockoutMolarActinsactin nucleationameloblastsCobl KO (knockout)cordon-bleucortical actin cytoskeletonenamel composition

Identifiers

PMID40072087
PMCPMC11898890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.