Evidence map›Paper›PMID 40071711›Full record

ArticleEuropean journal of immunology2025

Age and Latent Cytomegalovirus Infection Do Not Affect the Magnitude of De Novo SARS-CoV-2-Specific CD8

Jet van den Dijssel, Veronique A L Konijn, Mariël C Duurland, Rivka de Jongh, Lianne Koets, Barbera Veldhuisen, Hilde Raaphorst, Annelies W Turksma, Julian J Freen-van Heeren, Maurice Steenhuis and 7 more

Abstract read
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. CD8Cell reports. Medicine · 2026
    Review
  2. The ageing immune system and its battle with viruses.The Journal of general virology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jet van den DijsselSanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-4849-0374
Veronique A L KonijnSanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Mariël C DuurlandSanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Rivka de JonghSanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Lianne KoetsSanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Barbera VeldhuisenSanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Hilde RaaphorstR&D, Sanquin Diagnostic Services, Amsterdam, The Netherlands.
Annelies W TurksmaR&D, Sanquin Diagnostic Services, Amsterdam, The Netherlands.
Julian J Freen-van HeerenR&D, Sanquin Diagnostic Services, Amsterdam, The Netherlands.ORCID 0000-0003-0506-2756
Maurice SteenhuisSanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Theo RispensSanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-9600-1312
C Ellen van der SchootSanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
S Marieke van HamSanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Rene A W van LierDivision LAB, University Medical Center Utrecht, Utrecht, The Netherlands.
Klaas P J M van GisbergenSanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0003-3623-7555
Anja Ten BrinkeSanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Carolien E van de SandtSanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-4155-7433

Funding

Australian Research Council ARC-DECRA Fellowship / DE220100185Sanquin Blood Supply Project Grant PPOC / L2506University of Melbourne EstablishmentGrant
6 · The paper itself

Abstract

Immunosenescence, age-related immune dysregulation, reduces immunity upon vaccinations and infections. Cytomegalovirus (CMV) infection results in declining naïve (T

Indexed as

CD8-Positive T-LymphocytesCOVID-19Cytomegalovirus InfectionsLatent InfectionSARS-CoV-2AdultAge FactorsCohort StudiesCytomegalovirusEpitopes, T-LymphocyteFemaleHumansImmunity, CellularImmunologic MemoryImmunosenescenceMaleEpitopes, T-Lymphocyteagingantigen‐specific CD8+ T cellsCMVCOVID‐19immunosenescence

Identifiers

PMID40071711
PMCPMC11898545

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.