Evidence map›Paper›PMID 40071685›Full record

ArticleArchiv der Pharmazie2025

Anticholinesterase and carbonic anhydrase inhibitory activities of natural carnosic acid derivatives: A comprehensive in vitro and in silico study.

Zeynep Köksal, Halil Şenol

Abstract read
In one paragraph

Article in Archiv der Pharmazie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Rosemary (Iranian journal of basic medical sciences · 2026
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Zeynep KöksalDepartment of Chemistry, Faculty of Engineering and Natural Sciences, Istanbul Medeniyet University, Istanbul, Türkiye.ORCID http://orcid.org/0000-0002-0869-8517
Halil ŞenolDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, Istanbul, Türkiye.ORCID http://orcid.org/0000-0002-8333-035X

Funding

Istanbul Medeniyet University 2020-1614
6 · The paper itself

Abstract

This study investigates the anticholinesterase (acetylcholinesterase [AChE] and butyrylcholinesterase [BChE]) and carbonic anhydrase (CAI and CAII) inhibitory activities of carnosic acid and its natural derivatives, including carnosol, rosmanol, 7-methoxy-rosmanol, 12-methoxy-carnosic acid, and isorosmanol. Among the tested compounds, rosmanol demonstrated exceptional potency, with IC

Indexed as

AbietanesCarbonic Anhydrase InhibitorsCholinesterase InhibitorsAcetylcholinesteraseAnimalsButyrylcholinesteraseCarbonic Anhydrase ICarbonic AnhydrasesComputer SimulationDose-Response Relationship, DrugHumansMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureStructure-Activity RelationshipAbietanesAcetylcholinesteraseButyrylcholinesteraseCarbonic Anhydrase ICarbonic Anhydrase InhibitorsCarbonic AnhydrasesCholinesterase Inhibitorssalvinacetylcholinesterasebutyrylcholinesterasecarbonic anhydrasemolecular dockingrosmanol

Identifiers

PMID40071685
PMCPMC11898576

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.