ArticleJournal of cosmetic dermatology2025
Efficacy of Lifting Threads Composed of Poly(L-Lactide-Co-ε-Caprolactone) Copolymers Coated With Hyaluronic Acid: A Long-Term Study on Biorevitalizing Properties in Skin Remodeling.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Application of PLCL as a biodegradable polymer in biomedical engineering.Journal of materials science. Materials in medicine · 2026Review
- Non-Surgical Correction of Facial Asymmetry: A Narrative Review of Non-Surgical Modalities and Clinical Case Examples.Journal of clinical medicine · 2025Review
- Benefits of P(LA/CL)-Hyaluronic Acid Threads With Innovative Hyaluronic Acid Coating Technology (NAMICA)-Preclinical Test Results.Journal of cosmetic dermatology · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundFacial thread lifting, which is popular in aesthetic medicine because of its minimal invasiveness, has led to advancements in the use of biodegradable polymers such as poly(L-lactide-co-ε-caprolactone) (P(LA/CL)) and its hyaluronic acid-coated variant (P(LA/CL)-HA). These developments enhance biocompatibility and efficacy, offering prolonged benefits through better biostimulation and tissue integration.
methodsA controlled experiment involving five 4-month-old female pigs compared the effectiveness of P(LA/CL) and P(LA/CL)-HA threads over six months. After being implanted into the subcutaneous layer parallel to the skin of each pig, the threads were evaluated through histological analysis at intervals (7, 21, 30, 90, and 180 days) to assess changes in dermal and hypodermal structures, collagen types, elastin levels, and tissue integration via stains such as hematoxylin and eosin (H&E), Weigert-Van Gieson, and Sirius Red.
resultsP(LA/CL) and P(LA/CL)-HA threads significantly led to dermal and hypodermal remodeling. By day 180, a comparative analysis via the Wilcoxon test revealed that P(LA/CL)-HA significantly outperformed P(LA/CL) in most histological indicators because of the biostimulatory effects of hyaluronic acid.
conclusionsOur study investigated the effects of two types of bioabsorbable threads, P(LA/CL) and P(LA/CL)-HA, on skin remodeling over 180 days in a porcine model. These results highlight the significant role of thread composition in tissue remodeling and suggest that incorporating HA could optimize therapeutic and aesthetic outcomes. Further clinical research is necessary to confirm these findings in human subjects.
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Registered trials
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