Evidence map›Paper›PMID 40071595›Full record

ArticleThe Journal of antimicrobial chemotherapy2025

Comparison of antibiotic provision associated with acute sore throat symptom management in community pharmacies in Wales and England: a natural policy experiment.

Ayodeji Matuluko, Efi Mantzourani, Haroon Ahmed, Rebecca Cannings-John, Andrew Evans, Mirza Lalani, Nicholas Mays, Rebecca E Glover

Abstract readComparative Study
In one paragraph

Article in The Journal of antimicrobial chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ayodeji MatulukoDepartment of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0002-9778-8695
Efi MantzouraniCardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK.ORCID 0000-0002-6313-1409
Haroon AhmedDivision of Population Medicine, Cardiff University, Cardiff, UK.ORCID 0000-0002-0634-8548
Rebecca Cannings-JohnCentre for Trials Research, Cardiff University, Cardiff, UK.
Andrew EvansHealth Social Services and Early Years Group, Welsh Government, Cardiff, UK.ORCID 0000-0001-9486-283X
Mirza LalaniDepartment of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0001-7851-9062
Nicholas MaysDepartment of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0001-9808-8466
Rebecca E GloverDepartment of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0001-9150-9977

Funding

National Institute for Health Research (NIHR) Health and Social Care Delivery Research Programme NIHR160217
6 · The paper itself

Abstract

backgroundAcute sore throat is managed in community pharmacies in England and Wales under different clinical pathways: Acute Sore Throat Pharmacy First (ASTPF) and Sore Throat Test and Treat (STTT), respectively. ASTPF launched in 2024 and allows antibiotic supply with FeverPAIN scores 4 and 5. STTT launched in 2018 and allows antibiotic supply with FeverPAIN ≥2 or Centor ≥3, if point-of-care testing confirms presence of group A Streptococcus (GAS).

objectivesTo compare antibiotic supply rates of ASTPF and STTT, between 1 February 2024 and 30 July 2024, covering the first 6 months of ASTPF.

methodsA descriptive study using anonymized individual-level data from electronic pharmacy records of STTT and anonymized population-level aggregate data from electronic records of ASTPF consultations meeting the gateway criteria for reimbursement.

resultsDuring the study period, 317 864 ASTPF and 27 684 STTT consultations were recorded across participating pharmacies, representing 551.0 and 874.9 consultations per 100 000 population in England (57 690 300) and Wales (3 164 400), respectively. The antibiotic supply rate was 72.7% (95% CI: 72.5% to 72.8%) for ASTPF and 29.9% (95% CI: 29.4% to 30.5%) for STTT.

conclusionsIn this natural experiment in two similar healthcare systems with pharmacy-led sore throat services, we found different rates of antibiotic supply. Differences could be attributable to service implementation, pharmacists' initial training, engagement with GPs, pathway differences (e.g. gateway criteria and use of point-of-care tests), symptom severity, or most likely a combination of multiple factors. This early analysis suggests adapting the ASTPF pathway, to include point-of-care testing, could lead to reductions in unnecessary antibiotic supply.

Indexed as

Anti-Bacterial AgentsCommunity Pharmacy ServicesPharmaciesPharyngitisStreptococcal InfectionsAdultEnglandFemaleHumansMaleMiddle AgedStreptococcus pyogenesWalesAnti-Bacterial Agents

Identifiers

PMID40071595
PMCPMC12046402

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.