Evidence map›Paper›PMID 40071580›Full record

ArticlePediatric emergency care2025

Ophthalmology Examinations in Children With Skull Fractures and Underlying Focal Hemorrhage.

Karli Breeden, Cindy W Christian, Joanne N Wood, Gil Binenbaum, Daniel M Lindberg, Angela Bachim, Colleen J Bressler, Lori Frasier, Terra Frazier, Nicole R Johnson and 7 more

Abstract readMulticenter Study
In one paragraph

Article in Pediatric emergency care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Karli BreedenDivision of General Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania.
Cindy W ChristianDivision of General Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania.
Joanne N WoodDivision of General Pediatrics, Clinical Futures, and PolicyLab, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania.
Gil BinenbaumDivision of Ophthalmology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Daniel M LindbergDepartment of Emergency Medicine, The Kempe Center for the Prevention & Treatment of Child Abuse & Neglect, University of Colorado School of Medicine, Aurora, CO.
Angela BachimDepartment of Pediatrics, Division of Public Health Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX.
Colleen J BresslerDepartment of Pediatrics, Division of Pediatric Emergency Medicine, Division of Child Abuse Pediatrics, College of Medicine, Medical University of South Carolina, Charleston, SC.
Lori FrasierDepartment of Pediatrics , Penn State Children's Hospital,  Penn State Hershey College of Medicine, Penn State Hershey Medical Center, Center for the Protection of Children, Hershey, PA.
Terra FrazierDepartment of Pediatrics, Division of Child Adversity and Resilience, University of Missouri Kansas City, Medical School, Children's Mercy Hospital and Clinics, Kansas City, MO.
Nicole R JohnsonCenter for Safe and Healthy Children, University of Minnesota Medical School, Minneapolis, MN.
Natalie LaubRady Children's Hospital, University of California San Diego, San Diego, CA.
Megan M LetsonDepartment of Pediatrics, The Ohio State University College of Medicine, The Center for Family Safety & Healing, Nationwide Children's Hospital, Columbus, OH.
Tagrid Ruiz-MaldonadoDepartment of Pediatrics, University of Utah, Center for Safe & Healthy Families, Primary Children's Hospital, Salt Lake City, UT.
Matthew ValenteUPMC Children's Hospital of Pittsburgh, Pittsburgh.
Jenna KielyDivision of General Pediatrics, PolicyLab Children's Hospital of Philadelphia.
Jan LeonardDepartment of Biomedical and Health Informatics, Data Science and Biostatistics Unit, Children's Hospital of Philadelphia.
M Katherine HenryDepartment of Radiology, Division of General Pediatrics, Clinical Futures, Children's Hospital of Philadelphia.

Funding

CAPNET - Building Research Capacity in Child Abuse PediatricsR24HD098415 · NICHD · UNIVERSITY OF COLORADO DENVER · PI CAMPBELL, KRISTINE A, LINDBERG, DANIEL M · 2020 to 2024
$1.8M
AHRQ HHS K08 HS028847NICHD NIH HHS R24 HD098415
6 · The paper itself

Abstract

objectivesTo assess the frequency and yield of retinal examination in children below 2 years old undergoing abuse evaluations in the setting of skull fracture(s) and small underlying intracranial hemorrhage.

methodsThis cross-sectional study used CAPNET, a multicenter child physical abuse network, to identify children below 2 years with a skull fracture(s) and intracranial injury limited to an underlying small focal intracranial hemorrhage undergoing subspeciality child abuse evaluations. Our outcomes of interest were (1) the performance of a retinal examination, (2) the identification of retinal hemorrhages, and (3) associations of clinical factors and CAPNET site with the performance of retinal examinations. We hypothesized that retinal hemorrhages would be identified in <5% of patients.

resultsOf 242 children who met inclusion criteria, the majority (189, 78.1%) presented with a reported history of accidental trauma, and most (211, 87.2%) lacked additional injuries. Only 9 (3.7%) had loss of consciousness and/or seizures/seizure-like activity. The majority (201, 83.1%) had low concern for abuse. Overall, 104 (43.0%) children underwent retinal examinations, of which 0 had retinal hemorrhages (one-sided 95% CI: 0-2.8%). Children without a reported accidental mechanism of injury ( P =0.004), those with intermediate/high concern for abuse ( P <0.001), and children with occipital fractures ( P =0.008) were more likely than their counterparts to undergo retinal examination. The proportion of children undergoing retinal examination varied by CAPNET site ( P <0.001).

conclusionsOur findings suggest that it may be reasonable to forgo retinal examinations in children below 2 years of age with skull fracture(s) and intracranial injury limited to an underlying small focal hemorrhage who are overall neurologically well-appearing.

Indexed as

Child AbuseIntracranial HemorrhagesRetinal HemorrhageSkull FracturesCross-Sectional StudiesFemaleHumansInfantMaleCAPNETchild abuseophthalmology examinationsretinal hemorrhageskull fracture

Identifiers

PMID40071580
PMCPMC12272558

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.