Evidence map›Paper›PMID 40071564›Full record

ArticleEuropean stroke journal2025

Feasibility of telephone and computerized cognitive testing as a secondary outcome in an acute stroke clinical trial: A mixed methods sub-study of the AcT Trial.

Sajeevan Sujanthan, Pugaliya Puveendrakumaran, Katie N Dainty, Morgan Barense, Krista L Lanctot, Adrian M Owen, Nishita Singh, Brian H Buck, Houman Khosravani, Shelagh B Coutts and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European stroke journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Sajeevan SujanthanFaculty of Graduate Studies, Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-3128-3977
Pugaliya PuveendrakumaranDepartment of Medicine (Neurology), Hurvitz Brain Sciences Program, SB Centre for Brain Resilience and Recovery, Sunnybrook HSC, ON, Canada.
Katie N DaintyInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.
Morgan BarenseDepartment of Psychology, University of Toronto, Toronto, ON, Canada.
Krista L LanctotDepartment of Psychiatry, and Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
Adrian M OwenDepartment of Physiology & Pharmacology, Psychology, University of Western, Toronto, ON, Canada.
Nishita SinghDivision of Neurology, Rady Faculty of Medicine, University of Manitoba, Calgary, MB, Canada.
Brian H BuckDepartment of Medicine, Division of Neurology, University of Alberta, Edmonton, AB, Canada.
Houman KhosravaniDepartment of Medicine (Neurology), Hurvitz Brain Sciences Program, SB Centre for Brain Resilience and Recovery, Sunnybrook HSC, ON, Canada.
Shelagh B CouttsDepartment of Clinical Neurosciences and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Mohammed AlmekhlafiDepartment of Clinical Neurosciences and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Ramana AppireddyDepartment of Medicine, Division of Neurology, Queen's University, Kingston, ON, Canada.
Aleksander TkachKelowna General Hospital, Kelowna, BC, Canada.
Jennifer MandziaLondon Health Sciences Centre and Western University, London, ON, Canada.
Heather WilliamsQueen Elizabeth Hospital, Charlottetown, PE, Canada.
Thalia S FieldDivision of Neurology, University of British Columbia, Vancouver, BC, Canada.
Alejandro ManosalvaMedicine Hat Regional Hospital, Medicine Hat, AB, Canada.
Muzaffar SiddiquiGrey Nuns Community Hospital, Edmonton, AB, Canada.
Gary HunterUniversity of Saskatchewan, Saskatoon, SK, Canada.
MacKenzie HornDepartment of Clinical Neurosciences and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Fouzi BalaDiagnostic and Interventional Neuroradiology Department, University Hospital of Tours, Tours, France.ORCID 0000-0001-6748-2081
Michael D HillDepartment of Clinical Neurosciences and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID 0000-0002-6269-1543
Michel ShamyDepartment of Medicine, University of Ottawa, Ottawa, ON, Canada.
Aravind GaneshDepartment of Clinical Neurosciences and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Tolulope SajobiDepartment of Clinical Neurosciences and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Bijoy K MenonDepartment of Clinical Neurosciences and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Richard H SwartzFaculty of Graduate Studies, Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-6571-5531

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPost-stroke cognitive impairment is associated with impaired quality of life. Remote testing provides a potential avenue to measure cognitive outcomes efficiently. PATIENTS AND

methodsProspective cognitive outcomes were collected at 90-180 days using both telephone MoCA (T-MoCA; range 0-22; <17 impairment) and Creyos, a computerized cognitive battery. Key variables associated with completion were assessed using logistic regressions. Mixed methods brief structured interviews and exit survey were performed to explore barriers to completing computer testing.

resultsOf 791 potentially eligible patients (mean age 70 ± 14 years), there was low feasibility of remote cognitive testing, with only 401 (51%) completing the T-MoCA, and 242 (31%) completing Creyos. Our regression models show that age (OR DISCUSSION: Remote cognitive testing has limited feasibility as a secondary outcome in large acute stroke trials. Patients who are older, with worse quality of life, or severe functional impairment post-stroke are less likely to complete remote cognitive outcomes.

conclusionInnovative approaches to post-stroke cognitive outcomes in acute stroke trials are needed.Data AccessData available upon request.

Indexed as

Cognitive DysfunctionNeuropsychological TestsStrokeTelephoneAgedAged, 80 and overFeasibility StudiesFemaleHumansMaleMiddle AgedProspective StudiesQuality of Lifeclinical trialscognitive endpointcomputerized assessmentStroketelephone assessment

Identifiers

PMID40071564
PMCPMC11907497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.