Evidence map›Paper›PMID 40071323›Full record

ArticleJournal of developmental origins of health and disease2025

PedBE age and age acceleration in umbilical vein endothelial cells: an examination of infant birth outcomes.

Kristin M Voegtline, Radhika S Raghunathan, David W Sosnowski, Gang Peng, Cathrine Hoyo, Susan K Murphy, Raquel G Hernandez, Sara B Johnson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of developmental origins of health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Effects of Ambient Temperature During Pregnancy on Newborn Birthweight.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kristin M VoegtlineDepartment of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-2938-7718
Radhika S RaghunathanDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
David W SosnowskiDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Gang PengDepartment of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Cathrine HoyoDepartment of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
Susan K MurphyDepartment of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, USA.
Raquel G HernandezDepartment of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Sara B JohnsonDepartment of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Funding

Social adversities, epigenetics, and the obesity epidemicR01MD011746 · NIMHD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HOYO, CATHRINE · 2017 to 2021
$4.4M
NIMHD NIH HHS R01 MD011746
6 · The paper itself

Abstract

The current study examines the application of the Pediatric-Buccal-Epigenetic (PedBE) clock, designed for buccal epithelial cells, to endothelia. We evaluate the association of PedBE epigenetic age and age acceleration estimated from human umbilical vein endothelial cells (HUVECs) with length of gestation and birthweight in a racially and ethnically diverse sample (analytic sample

Indexed as

AgingEpigenesis, GeneticHuman Umbilical Vein Endothelial CellsAdultBirth WeightFemaleGestational AgeHumansInfantInfant, NewbornMalePregnancyepigenetic ageepigenetic age accelerationinfant birthoutcomesPedBE clockumbilical tissue

Identifiers

PMID40071323
PMCPMC12175094

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.