ArticleFrontiers in psychiatry2025
Randomized controlled trial to assess medication adherence and health-related quality of life through a collaborative pharmacist-psychiatrist approach to patient education in patients with depression in India.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluating the impact of pharmacists in outpatient mental health settings: a systematic review.International journal of clinical pharmacy · 2026Pooled it
- Treatment-Related Factors for Medication Non-Adherence Among Patients with Major Depressive Disorder: An Explanatory Sequential Mixed-Methods Study.Patient preference and adherence · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Depression is a common but severe mental health disorder affecting individuals globally. Medication non-adherence and low health-related quality of life (HRQoL) are the major challenges associated with the treatment of patients with depression. Materials and methods: A prospective Randomized Controlled Trial (RCT) was conducted in the psychiatry outpatient department of a tertiary care hospital for six months. Patients were assigned to either a control group receiving usual care or a test group receiving collaborative care using simple randomization technique. The eligible patients diagnosed with depression were enrolled and the data were collected from patient's care records, prescriptions, patient interviews, patient representatives and healthcare professionals. The intervention in the test group consisted of comprehensive patient education, including a thorough counseling session with a research clinical pharmacist. Counseling sessions included information on the disease, medications prescribed, possible side effects, compliance with medications and overall treatment. The data collected from both patient groups was analyzed for medication adherence using the Medication Adherence Rating Scale (MARS) and health-related quality of life (HRQoL) using the WHOQOL-BREF questionnaire. Statistical analyses were performed using a student t-test with a significance level of P value < 0.05. Results: The collaborative care group showed a statistically significant improvement in medication adherence, with a mean increase of 1.67 ± 0.25 (P < 0.001), compared with a mean increase of 0.69 ± 0.05 (P < 0.05) for the usual care group. Similarly, HRQoL scores also improved significantly more in the collaborative care group, with a mean increase of 28.01 ± 2.05 (P < 0.001), compared with a mean increase of 12.46 ± 0.26 (P < 0.05) for the usual care group. Conclusion: This study concluded that pharmacist-psychiatrist collaborative patient education can significantly improve the medication adherence and HRQoL of the patients with depression. Statistically significant increases in medication adherence and HRQoL were observed in the collaborative group.
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