ArticleInternational journal of endocrinology and metabolism2024
Association Between Essential Trace Elements and Thyroid Antibodies in the Blood of Women with Newly Diagnosed Hashimoto's Thyroiditis.
Article in International journal of endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Trial
- From copper imbalance to immunometabolic remodeling: cuproptosis-related vulnerability and therapeutic hypotheses in autoimmune diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Thyroid peroxidase gene variants and susceptibility to congenital hypothyroidism and autoimmune thyroid disease among Egyptian pediatric cohort.Clinical and experimental pediatrics · 2026Article
- Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The involvement of essential trace elements in the pathogenesis of Hashimoto's thyroiditis (HT) has been suggested, although the available evidence is limited. Objectives: The aim of this study was to investigate the interplay between serum selenium (Se), iron (Fe), zinc (Zn), and copper (Cu) status with thyroid auto-antibodies and thyroid echogenicity in women with newly diagnosed HT. Methods: A cohort of newly diagnosed female HTs (n = 56) and matched controls (n = 64) were recruited. Serum Se, Fe, Zn, and Cu were measured by furnace graphite atomic absorption spectrometry (FGAAS). Thyroid hormone profiles and thyroid autoantibodies were assessed via ELISA. Results: In HTs, mean serum Se, Fe, and Zn were significantly lower, while serum Cu was higher in HTs compared to controls (64.11 ± 20.75 vs. 92.3 ± 29.36 μg/L, 53.67 ± 14.09 vs. 70.38 ± 18.44 μg/dL, 64.38 ± 18.88 vs. 90.89 ± 29.99 μg/dL, and 101.18 ± 33.40 vs. 82.2 ± 26.82 μg/dL; all P < 0.001). Pearson correlation analysis revealed a significant inverse correlation between serum Se, Zn, and Cu with thyroid peroxidase antibody (TPO-Ab) and thyroglobulin antibody (Tg-Ab) levels (P < 0.001). While no significant correlation was observed between thyroid antibodies and serum Fe levels, logistic regression revealed associations between thyroid antibodies and serum Fe. Upon dividing serum Se and Zn into quartiles, there was a significant alteration in the levels of TPO-Ab and Tg-Ab, with a reduction in the levels of antibodies observed from the first quartile to the fourth quartile. Conclusions: We conclude that Se, Fe, and Zn deficiency, coupled with increased Cu levels, are associated with elevated thyroid antibodies in the setting of Hashimoto Thyroiditis.
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