Evidence map›Paper›PMID 40071162›Full record

ReviewJournal of medicine and life2025

Reviewing the complexities of horseshoe kidney: insights into embryogenesis and surgical considerations.

Ovidiu-Catalin Nechita, Daniel Badescu, Razvan-Ionut Popescu, Stefan Rascu, Razvan-Cosmin Petca, Justin Aurelian, Traian Constantin, Cristian-Valentin Toma, Viorel Jinga, Bogdan Geavlete

Abstract readReview
In one paragraph

Review in Journal of medicine and life, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ovidiu-Catalin NechitaDepartment of Urology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Daniel BadescuDepartment of Urology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Razvan-Ionut PopescuDepartment of Urology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Stefan RascuDepartment of Urology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Razvan-Cosmin PetcaDepartment of Urology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Justin AurelianDepartment of Urology, Prof. Dr. Theodor Burghele Clinical Hospital, Bucharest, Romania.
Traian ConstantinDepartment of Urology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Cristian-Valentin TomaDepartment of Urology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Viorel JingaDepartment of Urology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Bogdan GeavleteDepartment of Urology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Horseshoe kidney (HSK) is a common renal malformation with unique and complex characteristics. A systematic literature search was conducted using PubMed and ScienceDirect databases. Several theories have been proposed regarding HSK formation, such as the close apposition of the kidneys during ascent through an arterial fork, lateral flexion of the trunk, and caudal embryonic rotation. Emerging evidence from animal models implicates notochord signaling and the sonic hedgehog pathway in HSK formation. The isthmus, a defining feature of HSK, is hypothesized to arise from ectopic mesenchymal tissue. The surgical anatomy of HSK is complex, given the variability in location, orientation, and blood supply. Both arterial and venous anatomy exhibit significant variability, raising questions about whether anomalous blood supply is a cause or a consequence of abnormal renal position. The isthmus usually contains functional renal parenchyma and fusion between the kidneys, primarily at the lower pole. While it is often stated that the inferior mesenteric artery is "held back" at the L3 level, this anatomical configuration is present in only 40% of cases. The review highlights the need for further research and provides a comprehensive overview of HSK knowledge.

Indexed as

Embryonic DevelopmentFused KidneyKidneyAnimalsHumanscongenital anomalyHorseshoe kidneykidney anatomical abnormalitieskidney embryogenesisrenal fusionrenal vascular variations

Identifiers

PMID40071162
PMCPMC11891615

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.