Evidence map›Paper›PMID 40071157›Full record

SynthesisJournal of medicine and life2025

Comparing the efficacy and safety of bridging therapy vs. monotherapy in patients with minor stroke: a meta-analysis.

Abdulsalam Aleid, Saud Aldanyowi, Abdulmajeed Aljabr, Sami Almalki, Awn Alessa, Mostafa Alhodibi, Mohammed Alsuwaylih, Yousef Alanazi, Abbas Almutair

Abstract readMeta-AnalysisComparative StudyReview
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In one paragraph

Synthesis in Journal of medicine and life, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abdulsalam AleidDepartment of Surgery, Medical College, King Faisal University, Ahsa, Saudi Arabia.
Saud AldanyowiDepartment of Surgery, Medical College, King Faisal University, Ahsa, Saudi Arabia.
Abdulmajeed AljabrKing Saud bin Abdulaziz for Health Science, College of Medicine, Riyadh, Saudi Arabia.
Sami AlmalkiDepartment of Surgery, Medical College, King Faisal University, Ahsa, Saudi Arabia.
Awn AlessaDepartment of Neurosurgery, King Fahad Hospital, Hofuf, Ahsa, Saudi Arabia.
Mostafa AlhodibiPrimary Care, Al-Ahsa Health Cluster, Ahsa, Saudi Arabia.
Mohammed AlsuwaylihDepartment of Internal Medicine, Bahrain Defense Hospital, Riffa, Saudi Arabia.
Yousef AlanaziDepartment of Internal Medicine, Northern Border University, Arar, Saudi Arabia.
Abbas AlmutairResearch Center, Almoosa Hospital, Ahsa, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The two main therapeutic approaches for stroke treatment are endovascular thrombectomy, which involves mechanically removing the thrombus, and bridging therapy, which uses intravenous thrombolytics (IVT) prior to endovascular thrombectomy (EVT). This study aimed to compare monotherapy (EVT or IVT alone) with bridging therapy (IVT+EVT) in terms of efficacy and safety outcomes in patients with minor ischemic stroke. After a thorough screening, eight studies were included for qualitative synthesis and meta-analysis, comprising a total of 3,117 patients across the treatment arms. The main outcomes of interest were the efficacy of treatment modality, the rate of intracerebral hemorrhage (ICH), and mortality. In terms of functional outcomes measured by the Modified Rankin Score (mRs) 0-1, no significant difference was observed when comparing IVT monotherapy with bridging therapy (IVT+EVT), with an odds ratio of 0.79 (

Indexed as

Fibrinolytic AgentsStrokeThrombectomyThrombolytic TherapyEndovascular ProceduresHumansTreatment OutcomeFibrinolytic Agentsbridging therapyCI, Confidence Intervalendovascular thrombectomyEVT, Endovascular ThrombectomyGSR-ET, German Stroke Registry–Endovascular TreatmentI2, Statistical Measure of Study Heterogeneity Used in Meta-Analysisintravenous thrombolysisIVT, Intravenous ThrombolysisLVO, Large Vessel Occlusionmeta-analysisminor strokemonotherapymRs, Modified Rankin ScoreNIHSS, National Institutes of Health Stroke ScaleNOS, Newcastle-Ottawa ScaleOR, Odds RatioPRISMA, Preferred Reporting Items for Systematic Reviews and Meta-AnalysesRCT, Randomized Controlled TrialssICH, Symptomatic Intracranial HemorrhageSITS-ISTR, Safe Implementation of Treatments in Stroke–International Stroke Thrombolysis Registrysystematic review

Identifiers

PMID40071157
PMCPMC11891610

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.