Evidence map›Paper›PMID 40071092›Full record

ArticleFrontiers in oncology2025

Case Report: Prepubertal-type testicular teratoma with local metastasis in a postpubertal patient.

Olivia C Ghirardelli Smith, Alexander K Tsai, Minghao Zhong, Pegah Dejban, Andrew C Nelson, Michelle Dolan, Emmanuel S Antonarakis, Paari Murugan

Abstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Olivia C Ghirardelli SmithDepartment of Medicine, Division of Hematology, Oncology & Transplantation, University of Minnesota, Minneapolis, MN, United States.
Alexander K TsaiDepartment of Medicine, Division of Hematology, Oncology & Transplantation, University of Minnesota, Minneapolis, MN, United States.
Minghao ZhongDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States.
Pegah DejbanDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States.
Andrew C NelsonDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States.
Michelle DolanDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States.
Emmanuel S AntonarakisDepartment of Medicine, Division of Hematology, Oncology & Transplantation, University of Minnesota, Minneapolis, MN, United States.
Paari MuruganDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States.

Funding

TRAINING GRANT IN MICROBIOLOGY/CANCER RESEARCHT32CA009138 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Scott M. Dehm · 1985 to 2026
$11.3M
Investigating the local and systemic coordination of antiviral immunity by tissue-resident memory CD8 T cells in the skinF30AI181450 · NIAID · UNIVERSITY OF MINNESOTA · PI Olivia C. Smith · 2024 to 2026
$160k
NCI NIH HHS T32 CA009138NIAID NIH HHS F30 AI181450
6 · The paper itself

Abstract

Introduction: We report for the first time a case of a postpubertal patient presenting with a metastatic prepubertal-type testicular teratoma. Case discussion: A 29-year-old male with a history of corrected unilateral cryptorchidism presented with progressive bilateral lower extremity edema. Imaging revealed an inferior vena cava thrombus associated with a complex mass. A left testicular ultrasound identified a solid lesion suggestive of a germ cell tumor, leading to a left radical orchiectomy, which revealed a mature pure teratoma with no evidence of germ cell neoplasia Conclusion: This case illustrates that pure mature teratomas lacking chromosome 12p abnormalities, GCNIS, and other dysgenetic features, occurring in postpubertal males, cannot invariably be classified into the benign prepubertal-type teratoma category. Contrary to current paradigm, in rare cases these may represent tumors with metastatic potential.

Indexed as

germ cell neoplasia in situ (GCNIS)germ cell tumor (GCT)isochromosome 12p (i12p)postpubertal-type teratomaprepubertal-type teratomatesticular cancer

Identifiers

PMID40071092
PMCPMC11893418

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