Evidence map›Paper›PMID 40071073›Full record

ArticleSovremennye tekhnologii v meditsine2025

Spectroscopic Study of Methylene Blue Interaction with Coenzymes and its Effect on Tumor Metabolism.

D V Pominova, A V Ryabova, A S Skobeltsin, I V Markova, I D Romanishkin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sovremennye tekhnologii v meditsine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

D V PominovaPhD, Senior Researcher, Laser Biospectroscopy Laboratory, Light-Induced Surface Phenomena Department, Natural Sciences Center; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilov St., Moscow, 119991, Russia; Associate Professor, Department 87 "Laser Micro-, Nano-, and Biotechnologies, Engineering Physics Institute for Biomedicine"; National Research Nuclear University MEPhI, 31 Kashirskoye Highway, Moscow, 115409, Russia.
A V RyabovaSenior Researcher, Laser Biospectroscopy Laboratory, Light-Induced Surface Phenomena Department, Natural Sciences Center; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilov St., Moscow, 119991, Russia; Associate Professor, Department 87 "Laser Micro-, Nano-, and Biotechnologies, Engineering Physics Institute for Biomedicine"; National Research Nuclear University MEPhI, 31 Kashirskoye Highway, Moscow, 115409, Russia.
A S SkobeltsinJunior Researcher, Laser Biospectroscopy Laboratory, Light-Induced Surface Phenomena Department, Natural Sciences Center; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilov St., Moscow, 119991, Russia; Senior Teacher, Department 87 "Laser Micro-, Nano-, and Biotechnologies, Engineering Physics Institute for Biomedicine"; National Research Nuclear University MEPhI, 31 Kashirskoye Highway, Moscow, 115409, Russia.
I V MarkovaPhD Student; National Research Nuclear University MEPhI, 31 Kashirskoye Highway, Moscow, 115409, Russia; Engineer, of Laser Biospectroscopy Laboratory, Light-Induced Surface Phenomena Department, Natural Sciences Center; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilov St., Moscow, 119991, Russia.
I D RomanishkinJunior Researcher, Laser Biospectroscopy Laboratory, Light-Induced Surface Phenomena Department, Natural Sciences Center; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilov St., Moscow, 119991, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Materials and Methods: The MB interaction with NADH, FADH Results: NADH has been established to be the main coenzyme with which MB interacts. The reduction of the lactate quantity is mediated by the shift of tumor metabolism as a result of MB interaction with the NADH. In the experiments Conclusion: The possibility of using MB for the tumor metabolism correction and growth rate reduction has been demonstrated, however, the time of therapy and MB concentration should be optimized to obtain more pronounced therapeutic effect.

Indexed as

Carcinoma, Ehrlich TumorFlavin-Adenine DinucleotideLactic AcidMethylene BlueNADAnimalsMiceFlavin-Adenine DinucleotideLactic AcidMethylene BlueNADlactatemethylene blueNADH and FADH2 coenzymesspectroscopytime-resolved fluorescence microscopytumor metabolism

Identifiers

PMID40071073
PMCPMC11892571

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.