ReviewSovremennye tekhnologii v meditsine2025
Spheroids from Epithelial and Mesenchymal Cell Phenotypes as Building Blocks in Bioprinting (Review).
Review in Sovremennye tekhnologii v meditsine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Additive Manufacturing of Engineered Tissue Constructs: Current Strategies and Future Directions.Bioengineering (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most tissues and organs are based on cells of the epithelial and mesenchymal phenotypes. Epithelial cells build protective barriers, have a key role in absorption and secretion, and participate in metabolism. Characterized by high plasticity and ability to migrate, mesenchymal cells ensure structural support, promote tissue restoration and are important for matrix remodeling. Interaction between these two cell types is critical for maintaining the body integrity and functioning. Modern tissue engineering is aimed at creation of artificial tissues and organs that have the required cellular composition, mechanical properties and functional potential for medical usage. One of the most popular methods of tissue engineering is 3D bioprinting, which allows creating complex three-dimensional structures with specified characteristics. Recently, special attention has been paid to bioprinting with spheroids being three-dimensional cellular aggregates that can be used as building blocks for tissue-engineered structures. Due to numerous cell-to-cell contacts and accumulation of extracellular matrix, spheroids ensure conditions allowing to form anatomical tissues and organs. To optimize bioprinting conditions, one shall precisely understand the mechanical properties of spheroids, as they directly affect the ability of cells to migrate and fuse, and thus the rate of construct formation and its overall morphology. This review summarizes the available data on the differences in mechanical properties of epithelial and mesenchymal spheroids, examines methods for their co-culturing in various applications of regenerative medicine, as well as analyzes the peculiarities of their use in different bioprinting methods to obtain high-quality tissue constructs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.