ArticleGeneral psychiatry2025
Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China.
Article in General psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03672448 (Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine), which is not on this map. Cited by 11 papers.
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The trial behind it
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Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine
Who cites it
11 citing papers in PubMed.
- Effects of a Combined Vitamin DNutrients · 2026Trial
- Elevated endogenous glucagon-like peptide-1 as a novel Alzheimer's disease biomarker associated with neuroinflammation and Aβ pathology.General psychiatry · 2026Article
- Associations of Social Support, Loneliness, and Physical Activity with Cognitive Function in Older Adults with Mild Cognitive Impairment.Journal of clinical medicine · 2026Article
- Fusion of Multi-Paradigm EEG Microstate Features to Enhance the Recognition of Mild Cognitive Impairment.Brain and behavior · 2026Article
- Causal machine learning analysis identifies subpopulations most likely to benefit from healthy lifestyles for cognitive outcomes.General psychiatry · 2026Article
- A literature review of dementia literacy in China: From awareness to action as a driver of the 2024-2030 National Dementia Action Plan.General psychiatry · 2026Review
- Development and Validation of a Predictive Model for Mild Cognitive Impairment in Older Adults with Multimorbidity.Clinical interventions in aging · 2026Article
- Sociodemographic, health behavioral, and disease history risk factors for dementia in older adults: a population-based cross-sectional study in Guangzhou, China.Frontiers in public health · 2025Article
- Prevalence, associated factors and impact of mild cognitive impairment in hospitalized older adults with Parkinson's disease: a cross-sectional study.Frontiers in aging neuroscience · 2025Article
- Analysis of comorbid characteristics, molecular mechanisms between mild cognitive impairment and Alzheimer's disease with interventions in a community-based population in Shanghai.Frontiers in neurologyArticle
- Association between circulating biomarkers of one-carbon metabolism and glymphatic system function in cognitive decline of Alzheimer's disease.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
23 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: As the population in China rapidly ages, the prevalence of mild cognitive impairment (MCI) is increasing considerably. However, the causes of MCI vary. The continued lack of understanding of the various subtypes of MCI impedes the implementation of effective measures to reduce the risk of advancing to more severe cognitive diseases. Aims: To estimate the prevalence and incidence rates of two MCI subtypes-amnestic MCI (aMCI) and vascular cognitive impairment without dementia (VCIND)-and to determine modifiable factors for them among older individuals in a multiregional Chinese cohort. Method: This 1-year longitudinal study surveyed a random sample of participants aged≥60 years from a large, community-dwelling cohort in China. Baseline lifestyle data were self-reported, while vascular and comorbid conditions were obtained from medical records and physical examinations. In total, 3514 and 2051 individuals completed the baseline and 1-year follow-up assessments, respectively. Logistic and linear regression analyses were used to identify the modifiable factors for MCI subtypes and predictors of cognitive decline, respectively. Results: Among our participants, aMCI and VCIND demonstrated prevalence of 14.83% and 2.71%, respectively, and annual incidence (per 1000 person-years) of 69.6 and 10.6, respectively. The risk factor for aMCI was age, whereas its protective factors were high education level, tea consumption and physical activity. Moreover, VCIND risk factors were age, hypertension and depression. The presence of endocrine disease, cerebral trauma or hypertension was associated with a faster decline in cognition over 1 year. Conclusions: MCI is a serious health problem in China that will only worsen as the population ages if no widespread interventions are implemented. Preventive strategies that promote brain activity and support healthy lifestyle choices are required. We identified modifiable factors for MCI in older individuals. The easy-to-adopt solutions such as tea consumption and physical activity can aid in preventing MCI. Trial registration number: NCT03672448.
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