Evidence map›Paper›PMID 40070878›Full record

ArticleEuropean heart journal open2025

Ischaemic and bleeding risk after ST-elevation myocardial infarction in patients with active cancer: a nationwide study.

Mohamed Dafaalla, Francesco Costa, Haibo Jia, Harindra Wijeysundera, Muhammad Rashid, Michelle M Graham, Wojtek Wojakowski, Alaide Chieffo, Gary S Mintz, Mamas A Mamas

Abstract read
In one paragraph

Article in European heart journal open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. First quinquennium completed: highlights fromEuropean heart journal open · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohamed DafaallaKeele Cardiovascular Research Group, Centre for Prognosis Research, Keele University, Keele Rd, Keele ST5 5BG, UK.ORCID https://orcid.org/0000-0003-4625-2775
Francesco CostaDepartamento de Medicina UMA, Área del Corazón, Hospital Universitario Virgen de la Victoria, CIBERCV, IBIMA Plataforma BIONAND, Campus de Teatinos, 29010 Malaga, Spain.ORCID https://orcid.org/0000-0002-3097-2834
Haibo JiaThe Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, P. R. China.ORCID https://orcid.org/0000-0001-9968-4024
Harindra WijeysunderaDivision of Cardiology, Department of Medicine, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Room A202, Toronto, ON M4N 3M5, Canada.
Muhammad RashidKeele Cardiovascular Research Group, Centre for Prognosis Research, Keele University, Keele Rd, Keele ST5 5BG, UK.ORCID https://orcid.org/0000-0001-9725-1583
Michelle M GrahamMazankowski Alberta Heart Institute, University of Alberta, 11011-88 Avenue Edmonton, Alberta, Canada T6G 2G5.
Wojtek WojakowskiDepartment of Cardiology and Structural Heart Diseases, Medical University of Silesia, Bankowa 12, 40-005 Katowice, Silesian Voivodeship, Poland.
Alaide ChieffoIRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Olgettina Street, 58 - 20132 Milan, Italy.
Gary S MintzCardiovascular Research Foundation, New York, NY, USA.
Mamas A MamasKeele Cardiovascular Research Group, Centre for Prognosis Research, Keele University, Keele Rd, Keele ST5 5BG, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Treatment of patients with cancer presenting with ST-elevation myocardial infarction (STEMI) is complex given the increased risk of both thrombotic and major bleeding complications. Methods and results: A nationally linked cohort of STEMI patients between January 2005 and March 2019 was obtained from the UK Myocardial Infarction National Audit Project and the UK National Hospital Episode Statistics Admitted Patient Care registries. The primary outcomes were major bleeding and re-infarction at 1 year following admission with STEMI. Major bleeding was defined as bleeding events that require hospital admission. Re-infarction was defined as acute MI according to the fourth Universal Definition of Myocardial Infarction. A total of 322 776 STEMI-indexed admissions were identified between January 2005 and March 2019. Of those, 7050 (2.2%) patients were diagnosed with active cancer. Cancer patients were older with more cardiovascular comorbidities. Cancer patients received invasive coronary angiography (62.2% vs. 72.7%, Conclusion: Compared with non-cancer patients, cancer patients have a higher risk of major bleeding but not of re-infarction. Mitigating bleeding risk in STEMI patients with cancer is of paramount importance to improve outcomes.

Indexed as

BleedingCancerOutcomesRe-infarction

Identifiers

PMID40070878
PMCPMC11892560

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.