Evidence map›Paper›PMID 40070864›Full record

ArticleBalkan journal of medical genetics : BJMG2024

In Vitro Analysis of AKR1D1 Interactions with Clopidogrel: Effects on Enzyme Activity and Gene Expression.

K Shutevska, Panovska T Kadifkova, Z Zhivikj, Nestorovska A Kapedanovska

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Article in Balkan journal of medical genetics : BJMG, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

K ShutevskaUniversity Ss Cyril and Methodius in Skopje, Faculty of Pharmacy, Institute of applied biochemistry, Majka Tereza 47, 1000 Skopje, Republic of North Macedonia.
Panovska T KadifkovaUniversity Ss Cyril and Methodius in Skopje, Faculty of Pharmacy, Institute of applied biochemistry, Majka Tereza 47, 1000 Skopje, Republic of North Macedonia.
Z ZhivikjUniversity Ss Cyril and Methodius in Skopje, Faculty of Pharmacy, Institute of applied biochemistry, Majka Tereza 47, 1000 Skopje, Republic of North Macedonia.
Nestorovska A KapedanovskaUniversity Ss Cyril and Methodius in Skopje, Faculty of Pharmacy, Institute of pharmaceutical chemistry, Majka Tereza 47, 1000 Skopje, Republic of North Macedonia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clopidogrel, a P2Y12 receptor antagonist, is widely used to prevent cardiovascular events, but significant variability in its efficacy persists among patients. AKR1D1, involved in bile acid synthesis and regulation of CYP enzymes, may contribute to this variability. This study aims to investigate whether clopidogrel and its inactive metabolite, 2-oxoclopidogrel, interact with AKR1D1 at the enzymatic or transcriptional level. Enzymatic activity assays demonstrated that neither clopidogrel nor 2-oxoclopidogrel acts as a substrate or inhibitor of AKR1D1. Expression studies in HepG2 cells further revealed no significant changes in

Indexed as

AKR1D1clopidogreldrug metabolismenzyme interactiongene expressionpharmacogenomics

Identifiers

PMID40070864
PMCPMC11892939

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.