Evidence map›Paper›PMID 40070854›Full record

ArticleWorld journal of biological chemistry2025

Bioactivity of dressings based on platelet-rich plasma and Platelet-rich fibrin for tissue regeneration in animal model.

João Abel Sá-Oliveira, Monique Vieira Geraldo, Milena Marques, Rafael Messias Luiz, Filipe Krasinski Cestari, Ingrid Nascimento Lima, Thayná Cristine De Souza, Ana Carla Zarpelon-Schutz, Kádima Nayara Teixeira

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Article in World journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

João Abel Sá-OliveiraPrograma Multicêntrico de Pós-graduação em Bioquímica e Biologia Molecular - Setor Palotina, Universidade Federal do Paraná, Palotina 85950-000, Paraná, Brazil.
Monique Vieira GeraldoCampus Toledo, Universidade Federal do Paraná, Toledo 85919-899, Paraná, Brazil.
Milena MarquesCampus Toledo, Universidade Federal do Paraná, Toledo 85919-899, Paraná, Brazil.
Rafael Messias LuizCampus Toledo, Universidade Federal do Paraná, Toledo 85919-899, Paraná, Brazil.
Filipe Krasinski CestariPatologia, Laboratório Prevenção Patologia, Cascavel 85810-040, Paraná, Brazil.
Ingrid Nascimento LimaCampus Toledo, Universidade Federal do Paraná, Toledo 85919-899, Paraná, Brazil.
Thayná Cristine De SouzaMedicina-Campus Toledo, UFPR - Universidade Federal do Paraná, Toledo 85919-899, Paraná, Brazil.
Ana Carla Zarpelon-SchutzCampus Toledo, Universidade Federal do Paraná, Toledo 85919-899, Paraná, Brazil.
Kádima Nayara TeixeiraPrograma Multicêntrico de Pós-graduação em Bioquímica e Biologia Molecular - Setor Palotina, Universidade Federal do Paraná, Palotina 85950-000, Paraná, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSkin wounds are common injuries that affect quality of life and incur high costs. A considerable portion of healthcare resources in Western countries is allocated to wound treatment, mainly using mechanical, biological, or artificial dressings. Biological and artificial dressings, such as hydrogels, are preferred for their biocompatibility. Platelet concentrates, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), stand out for accelerating tissue repair and minimizing risks of allergies and rejection. This study developed PRF and PRP-based dressings to treat skin wounds in an animal model, evaluating their functionality and efficiency in accelerating the tissue repair process.

aimTo develop wound dressings based on platelet concentrates and evaluating their efficiency in treating skin wounds in Wistar rats.

methodsWistar rats, both male and female, were subjected to the creation of a skin wound, distributed into groups (

resultsThe PRF-based dressing was more effective in accelerating wound closure early in the tissue repair process (up to D7), while PRF + CaCl

conclusionThe PRF-based dressing was effective in accelerating the closure of cutaneous wounds in Wistar rats early in the process and in aiding tissue repair at the later stages.

Indexed as

Murine modelPlatelet-rich fibrinPlatelet-rich plasmaSkin woundTissue repair

Identifiers

PMID40070854
PMCPMC11891554

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.