Evidence map›Paper›PMID 40070830›Full record

ArticleFrontiers in immunology2025

Cellular and molecular determinants mediating the dysregulated germinal center immune dynamics in systemic lupus erythematosus.

Spiros Georgakis, Kalliopi Ioannidou, Bernat Bramon Mora, Michail Orfanakis, Cloe Brenna, Yannick D Muller, Perla M Del Rio Estrada, Ashish A Sharma, Giuseppe Pantaleo, Laurence de Leval and 3 more

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Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Spiros Georgakis *Department of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
Kalliopi Ioannidou *Department of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
Bernat Bramon MoraBiomedical Data Science Center, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
Michail OrfanakisDepartment of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
Cloe BrennaDepartment of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
Yannick D MullerService of Immunology and Allergy, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Perla M Del Rio EstradaPathology Advanced Translational Research Unit, Department of Pathology, Emory University School of Medicine, Atlanta, GA, United States.
Ashish A SharmaPathology Advanced Translational Research Unit, Department of Pathology, Emory University School of Medicine, Atlanta, GA, United States.
Giuseppe PantaleoService of Immunology and Allergy, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Laurence de LevalDepartment of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
Denis ComteService of Internal Medicine, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Raphael GottardoBiomedical Data Science Center, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
Constantinos PetrovasDepartment of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Systemic lupus erythematosus (SLE) is characterized by dysregulated humoral immunity, leading to the generation of autoreactive B cells that can differentiate both within and outside of lymph node (LN) follicles. Methods: Here, we employed spatial transcriptomics and multiplex imaging to investigate the follicular immune landscaping and the Results: Our spatial transcriptomic analysis revealed robust type I IFN and plasma cell signatures in SLE compared to reactive, control follicles. Cell deconvolution revealed that follicular T cell subsets are mainly affected by the type I IFN fingerprint of SLE follicles. Dysregulation of T Discussion: Taken together, our findings highlight the altered immunological landscape of SLE follicles, likely fueled by potent inflammatory signals such as sustained type I IFN and/or IL-21 signaling. Our work provides novel insights into the spatial molecular and cellular signatures of SLE follicular B and T

Indexed as

B-LymphocytesGerminal CenterLupus Erythematosus, SystemicAdultCell DifferentiationFemaleGene Expression ProfilingHumansInterferon Type ILymph NodesMaleMiddle AgedT Follicular Helper CellsTranscriptomeInterferon Type Iage-associated B cellsgerminal center responseIL-4systemic lupus erythematosus (SLE)T follicular helper cells (TFH)type I IFN

Identifiers

PMID40070830
PMCPMC11894538

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.