ArticleOncology letters2025
Carfilzomib inhibits the progression of hepatocellular cancer by upregulating GADD45α expression.
Article in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Pathobiology of thymic epithelial tumours and the treatment strategy based on immuno-oncological characteristics: a narrative review.Mediastinum (Hong Kong, China) · 2026Review
- Preparation of Dual-Drug-Loaded Liver-Targeted Liposomes Co-Modified with SP94 Peptide and TAT Peptide.Current drug delivery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocellular carcinoma (HCC) ranks among the most prevalent and lethal cancers affecting humans. Currently, there are limited effective treatments available for HCC. Carfilzomib, a proteasome inhibitor, is known to exert anti-HCC activities; however, its underlying mechanisms of action remain unclear. In the present study, the efficacy of carfilzomib against HCC was evaluated and its underlying mechanisms were explored. Cell Counting Kit-8, 5-ethynyl-2-deoxyuridine staining and colony formation assays were employed to analyze the antiproliferative effect of carfilzomib on MHCC-97H and Huh7 cells. Additionally, flow cytometry was used to assess the effect of carfilzomib on the cell cycle and Transwell assays were used to evaluate the effect of carfilzomib on cell migration and invasion. Western blotting was utilized to examine the protein expression levels associated with cell cycle arrest. Furthermore, short hairpin RNA (shRNA) transfection was used to investigate the role of DNA damage inducible α (GADD45α) on carfilzomib-induced cell cycle arrest. A xenograft tumor model using nude mice was employed to evaluate the anti-HCC activity of carfilzomib
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