ArticleIndian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India2025
Nasal irrigation solution is less cytotoxic to nasal epithelial cells than nasal spray.
Article in Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Recent studies have demonstrated that corticosteroid delivered by nasal irrigation is superior to nasal spray in the treatment of chronic rhinosinusitis patients who have undergone sinus surgery. However, the local cytotoxicity of both delivery methods has not been previously evaluated. In this study we aimed to evaluate the cytotoxicity of corticosteroid prepared nasal irrigation solution and commercially available corticosteroid nasal spray. Methods: Primary human nasal epithelial air-liquid interface 3D cultures established from nasal brushes from patients with nasal diseases with polyps, and healthy nasal mucosa ( Results: Nasal irrigation using standard therapeutic concentrations of mometasone or budesonide demonstrated less cytotoxicity when compared to nasal spray of mometasone and fluticasone in stock concentration prescribed by the manufacturer. Nasal spray diluted by a factor of 10 demonstrated similar cytotoxicity to nasal irrigation using therapeutic concentration. This study reinforces the suspicion that it is not the drugs themselves but benzalkonium chloride that is the most involved in cytotoxicity. Conclusion: Corticosteroid irrigation is less cytotoxic than corticosteroid spray to nasal epithelial cells.
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