Evidence map›Paper›PMID 40070698›Full record

ArticleOpen forum infectious diseases2024

Seroprevalence of Cytomegalovirus Among Pregnant Women at Kawempe National Referral Hospital, Uganda: A Cross-sectional Study.

Richard V Katungye, Moses Musooko, Musa Sekikubo, Tobius Mutabazi, Mary Kyohere, Valerie Tusubira, Juliet Nsimire Sendagala, Joseph Peacock, Kirsty Le Doare, Annettee Nakimuli and 1 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Richard V KatungyeDepartment of Obstetrics and Gynaecology, Makerere University College of Health Sciences, Kampala, Uganda.
Moses MusookoDepartment of Obstetrics and Gynaecology, Makerere University College of Health Sciences, Kampala, Uganda.
Musa SekikuboDepartment of Obstetrics and Gynaecology, Makerere University College of Health Sciences, Kampala, Uganda.ORCID https://orcid.org/0000-0002-7335-9650
Tobius MutabaziDirectorate of Health Services, Special Forces Command, Uganda People's Defense Forces, Entebbe, Uganda.ORCID https://orcid.org/0000-0001-6711-1416
Mary KyohereMakerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda.
Valerie TusubiraMakerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda.ORCID https://orcid.org/0000-0002-3395-8755
Juliet Nsimire SendagalaMedical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.
Joseph PeacockInstitute for Infection and Immunity, St. George's, University of London, London, UK.ORCID https://orcid.org/0000-0002-8767-7377
Kirsty Le DoareMakerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda.ORCID https://orcid.org/0000-0002-5104-085X
Annettee NakimuliDepartment of Obstetrics and Gynaecology, Makerere University College of Health Sciences, Kampala, Uganda.ORCID https://orcid.org/0000-0003-2806-0243
PROGRESS Study Author Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Maternal primary cytomegalovirus (CMV) infection is associated with abortion and congenital anomalies. In Uganda, the burden of maternal CMV infection is not well studied. This study thus assessed the seroprevalence and factors associated with CMV infection among pregnant women at Kawempe National Referral Hospital in Kampala. This work forms a part of the PROGRESS study, an observational cohort study undertaken in Kampala, Uganda, between November 2018 and April 2021. Methods: We conducted a cross-sectional study between September 2020 and January 2021 among the 639 pregnant women admitted to the labor ward at a government hospital. Sociodemographic, medical, obstetric, and socioeconomic data were collected. Blood samples from study participants were drawn and analyzed for the presence of CMV immunoglobulin G (IgG) and IgM using enzyme-linked immunosorbent assay-based quantitative assays. Further analysis of all IgM-positive samples was conducted using CMV IgG avidity assays. All infants had a nasal polymerase chain reaction (PCR) on the first day of life to investigate CMV positivity. Logistic regression was performed to determine the factors associated with CMV infection. Results: Seroprevalence of CMV IgG among the 637 women was universal (100%), and that of CMV (IgM) was 5.8% (37/637). CMV (IgM) was associated with being low socioeconomic status (odds ratio, 3.44; 95% CI, 1.05-11.32; Conclusions: Universally, by the time women in Kampala conceive, they will have been exposed to CMV. Women of lower socioeconomic status were more likely to have recent CMV infection than their more affluent counterparts, highlighting the need for screening guidelines in this setting.

Indexed as

CMVinfantspregnant womenseropositivityUganda

Identifiers

PMID40070698
PMCPMC11891130

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.