Evidence map›Paper›PMID 40070668›Full record

ArticleFrontiers in neurology2025

Integrated multi-biomarker panel of CXCL13, HS-CRP, and WBC counts predicts outcomes in stroke neurosyphilis patients treated with HBO and TUS-NMES.

Wenchao He, Shuangshuang Chen, Ruyang Chen, Jun Zhang, Xuehua Zhang, Minzhi Wu, Dan Zhang, Fengfeng Zhu, Fanghua He, Yating Xv and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Infection and immunity · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Wenchao He *Department of Rehabilitation, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Disease Hospital, Suzhou Medical College of Soochow University, Suzhou, China.
Shuangshuang Chen *Department of Rehabilitation, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Disease Hospital, Suzhou Medical College of Soochow University, Suzhou, China.
Ruyang Chen *Department of Rehabilitation, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Disease Hospital, Suzhou Medical College of Soochow University, Suzhou, China.
Jun Zhang *Hospital Department, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Disease Hospital, Suzhou Medical College of Soochow University, Suzhou, China.
Xuehua Zhang *Hospital Department, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Disease Hospital, Suzhou Medical College of Soochow University, Suzhou, China.
Minzhi WuDepartment of Dermatology, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Disease Hospital, Suzhou Medical College of Soochow University, Suzhou, China.
Dan ZhangDepartment of Rehabilitation, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Disease Hospital, Suzhou Medical College of Soochow University, Suzhou, China.
Fengfeng ZhuIntensive Care Unit, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Disease Hospital, Suzhou Medical College of Soochow University, Suzhou, China.
Fanghua HeDepartment of Dermatology, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Disease Hospital, Suzhou Medical College of Soochow University, Suzhou, China.
Yating XvDepartment of Dermatology, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Disease Hospital, Suzhou Medical College of Soochow University, Suzhou, China.
Na LeiDepartment of Dermatology, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Disease Hospital, Suzhou Medical College of Soochow University, Suzhou, China.
Wenhui ZhengClinical Laboratory, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Disease Hospital, Suzhou Medical College of Soochow University, Suzhou, China.
Xinyi ShanDepartment of Rehabilitation, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Disease Hospital, Suzhou Medical College of Soochow University, Suzhou, China.
Jun DaiDepartment of Rehabilitation, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Disease Hospital, Suzhou Medical College of Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Neurosyphilis results from Objective: This study evaluates the predictive value and clinical significance of CXCL13, WBC, and Hs-CRP levels in neurosyphilis patients undergoing HBO and TUS-NMES therapy. Methods: The study included 158 neurosyphilis stroke patients treated from June 2022 to January 2024. Assessments of limb motor, cognitive functions, daily living abilities, and cerebrospinal fluid biomarkers were conducted pre- and post-four weeks of combined therapy. Results: After treatment, there was a significant improvement in FMA, MoCA, and MBI scores ( Conclusion: HBO and TUS-NMES significantly enhance recovery in neurosyphilis stroke patients. CXCL13, WBC, and Hs-CRP effectively predict rehabilitation outcomes, highlighting their value in clinical management.

Indexed as

biomarkersC-X-C motif chemokine ligand 13hyperbaric oxygenstroke neurosyphilistranscranial ultrasound neuromuscular stimulation

Identifiers

PMID40070668
PMCPMC11894733

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