ArticleFrontiers in endocrinology2025
Association of the Chinese visceral adiposity index with marrow adiposity in postmenopausal females.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the relationship between the Chinese visceral adiposity index (CVAI) and vertebral proton density fat fraction (PDFF). Methods: The study included 181 postmenopausal females including 53 normal bone mineral density (BMD), 88 osteopenia, and 40 osteoporosis. Vertebral marrow PDFF was measured using Fat Analysis & Calculation Technique imaging, and BMD was assessed via dual-energy X-ray absorptiometry. Bone turnover biomarkers and lipid metabolism were evaluated. The relationship between CVAI and PDFF was assessed using multivariable linear regression models, generalized additive models, and threshold effect analysis. Results: The mean BMD at the lumbar spine increased, and PDFF significantly decreased as quartiles of CVAI increased ( Conclusions: CVAI exhibited a nonlinear negative association with marrow adiposity within a suitable range, once CVAI crossed a definite threshold, PDFF ceased to increase. This finding suggests that a moderate visceral fat accumulation may enhance skeletal integrity, while excessive visceral fat could potentially have detrimental effects.
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