Evidence map›Paper›PMID 40070489›Full record

ArticleFrontiers in human neuroscience2025

Evidence of physiological changes associated with single-session pre-frontal tDCS: a pilot study.

Hannah N Rembrandt, Ellyn A Riley

Abstract read
In one paragraph

Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hannah N RembrandtAphasia Lab, Department of Communication Sciences and Disorders, Syracuse University, Syracuse, NY, United States.
Ellyn A RileyAphasia Lab, Department of Communication Sciences and Disorders, Syracuse University, Syracuse, NY, United States.

Funding

Pre-Frontal tDCS as a novel intervention to reduce effects of post-stroke fatigue while improving language and attention in aphasiaR01DC021677 · NIDCD · SYRACUSE UNIVERSITY · PI Ellyn Riley · 2025 to 2026
$1.5M
Improving Aphasia Outcomes through tDCS-Mediated Attention ManagementR21DC017787 · NIDCD · SYRACUSE UNIVERSITY · PI RILEY, ELLYN · 2020 to 2022
$458k
NIDCD NIH HHS R01 DC021677NIDCD NIH HHS R21 DC017787
6 · The paper itself

Abstract

Objective: Transcranial direct current stimulation (tDCS), a non-invasive, painless method of applying direct current electrical stimulation to specific areas of the brain, is an effective method for enhancing attention and post-stroke fatigue, as shown by behavioral improvements in post-stroke populations. While behavioral evidence supports this method, there is a paucity of physiological data corroboration of this improvement. The current study is designed to investigate if a single session of tDCS will improve attention and fatigue as shown by relevant physiological methods in persons with post-stroke aphasia. Methods: Ten participants (5 male; mean age: 62.8) engaged in two identically structured data collection sessions with at least a 3-day wash-out period between them. Sessions started with a sustained attention task with simultaneous electroencephalography (EEG) and pupillometry data collection, followed by an attention training program with simultaneous active or sham tDCS. Following tDCS, participants repeated the sustained attention task with simultaneous EEG and pupillometry data collection. Participants received active tDCS during one session, and sham tDCS during the other, with the order randomized. Results: No differences between conditions were found for either behavioral results from the sustained attention task (i.e., reaction time of correct responses; Conclusion: Changes in pupil diameter observed in the active stimulation condition suggest activation of the locus coeruleus-norepinephrine (LC-NE) pathway within a single session of tDCS administration, but the lack of significant changes for either response time or attention states indicate no direct effect on behaviorally measured or EEG measured attention within the same timeframe. Responses to active stimulation in terms of subjective fatigue rating varied between individual participants; overall, active tDCS mitigated task-based fatigue. More research is needed to investigate this relationship.

Indexed as

aphasiaattentionEEGpupillometrytDCS

Identifiers

PMID40070489
PMCPMC11893991

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.