Evidence map›Paper›PMID 40070487›Full record

ArticleFrontiers in human neuroscience2025

Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications.

Alfonso Enrique Martinez-Nunez, Christopher J Rozell, Simon Little, Huiling Tan, Stephen L Schmidt, Warren M Grill, Miroslav Pajic, Dennis A Turner, Coralie de Hemptinne, Andre Machado and 39 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. RF Power, BSensors (Basel, Switzerland) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

49 authors.

Alfonso Enrique Martinez-NunezNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States.
Christopher J RozellSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, United States.
Simon LittleMovement Disorders and Neuromodulation Centre, University of California San Francisco, San Francisco, CA, United States.
Huiling TanMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Stephen L SchmidtDepartments of Biomedical Engineering, Electrical and Computer Engineering, Neurobiology and Neurosurgery, Duke University and Duke University Medical Center, Durham, NC, United States.
Warren M GrillDepartments of Biomedical Engineering, Electrical and Computer Engineering, Neurobiology and Neurosurgery, Duke University and Duke University Medical Center, Durham, NC, United States.
Miroslav PajicDepartments of Biomedical Engineering, Electrical and Computer Engineering, Neurobiology and Neurosurgery, Duke University and Duke University Medical Center, Durham, NC, United States.
Dennis A TurnerDepartments of Biomedical Engineering, Electrical and Computer Engineering, Neurobiology and Neurosurgery, Duke University and Duke University Medical Center, Durham, NC, United States.
Coralie de HemptinneNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States.
Andre MachadoCenter for Neurological Restoration, Cleveland Clinic, Cleveland, OH, United States.
Nicholas D SchiffWeill Cornell Medical College, Feil Family Brain and Mind Research Institute, New York, NY, United States.
Abbey S Holt-BeckerRestorative Therapies Group Implantables, Research, and Core Technology, Medtronic Inc., Minneapolis, MN, United States.
Robert S RaikeRestorative Therapies Group Implantables, Research, and Core Technology, Medtronic Inc., Minneapolis, MN, United States.
Mahsa MalekmohammadiDepartment of Neurosurgery, University of California, Los Angeles, CA, United States.
Yagna J PathakNeuromodulation Division, Abbott, Plano, TX, United States.
Lyndahl HimesNeuromodulation Division, Abbott, Plano, TX, United States.
David GreeneNeuroPace, Inc., Mountain View, CA, United States.
Lothar KrinkeNewronika SpA, Milan, Italy.
Mattia ArlottiNewronika SpA, Milan, Italy.
Lorenzo RossiNewronika SpA, Milan, Italy.
Jacob RobinsonDepartment of Bioengineering, Rice University, Houston, TX, United States.
Bahne H BahnersDepartment of Neurology, Brigham & Women's Hospital, Harvard Medical School, Center for Brain Circuit Therapeutics, Boston, MA, United States.
Vladimir LitvakWellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, London, United Kingdom.
Luka MilosevicClinical and Computational Neuroscience, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Saadi GhatanDepartment of Neurosurgery, Mount Sinai Medical Center, New York, NY, United States.
Frederic L W V J SchaperDepartment of Neurology, Brigham & Women's Hospital, Harvard Medical School, Center for Brain Circuit Therapeutics, Boston, MA, United States.
Michael D FoxDepartment of Neurology, Brigham & Women's Hospital, Harvard Medical School, Center for Brain Circuit Therapeutics, Boston, MA, United States.
Nicholas M GreggDepartment of Neurology, Mayo Clinic, Rochester, MN, United States.
Cynthia KubuCenter for Neurological Restoration, Cleveland Clinic, Cleveland, OH, United States.
James J JordanoDepartment of Neurology, Georgetown University Medical Center, Washington, DC, United States.
Nicola G CascellaDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
YoungHoon NhoDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States.
Casey H HalpernDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States.
Helen S MaybergNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Ki Sueng ChoiNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Haneul SongNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Jungho ChaNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Sankaraleengam AlagapanSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, United States.
Nico U F DosenbachDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, United States.
Evan M GordonDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, United States.
Jianxun RenChangping Laboratory, Beijing, China.
Hesheng LiuChangping Laboratory, Beijing, China.
Lorraine V KaliaEdmond J Safra Program in Parkinson's Disease, Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Sarah-Anna HeschamSchool for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands.
Dorian M KusykNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States.
Adolfo Ramirez-ZamoraNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States.
Kelly D FooteNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States.
Michael S OkunNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States.
Joshua K WongNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States.

Funding

Electrophysiological Biomarkers to Optimize DBS for DepressionUH3NS103550 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MAYBERG, HELEN S, RIVA-POSSE, PATRICIO · 2017 to 2023
$7.7M
An Integrated Biomarker Approach to Personalized, Adaptive Deep Brain Stimulation in Parkinson DiseaseUH3NS129898 · NINDS · DUKE UNIVERSITY · PI DENNIS Alan TURNER · 2023 to 2026
$3.7M
Uncovering the neurophysiology of motivation in Parkinson™s disease with implanted adaptive brain stimulationK23NS120037 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LITTLE, SIMON · 2021 to 2024
$809k
NINDS NIH HHS K23 NS120037NINDS NIH HHS UH3 NS103550NINDS NIH HHS UH3 NS129898
6 · The paper itself

Abstract

The Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily on the novel uses of existing technology as well as next-generation technology. Our keynote speaker shared the vision of using neuro artificial intelligence to predict depression using brain electrophysiology. Innovative applications are currently being explored in stroke, disorders of consciousness, and sleep, while established treatments for movement disorders like Parkinson's disease are being refined with adaptive stimulation. Neuromodulation is solidifying its role in treating psychiatric disorders such as depression and obsessive-compulsive disorder, particularly for patients with treatment-resistant symptoms. We estimate that 300,000 leads have been implanted to date for neurologic and neuropsychiatric indications. Magnetoencephalography has provided insights into the post-DBS physiological changes. The field is also critically examining the ethical implications of implants, considering the long-term impacts on clinicians, patients, and manufacturers.

Indexed as

deep brain stimulationdepressionepilepsyneuromodulationobsessive-compulsive disorderParkinson’s diseasesleepstroke

Identifiers

PMID40070487
PMCPMC11893992

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.