Evidence map›Paper›PMID 40070337›Full record

ArticleJournal of the Royal Society, Interface2025

A comparison of electrospinning and pressurized gyration: Production of empagliflozin-loaded polylactic acid/polycaprolactone fibrous patches.

Humeyra Betul Yekeler, Ilke Kabaoglu, Ece Guler, Manuel Pedro F Graça, Oguzhan Gunduz, Deepak M Kalaskar, Muhammet Emin Cam

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Royal Society, Interface, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Humeyra Betul YekelerDepartment of Pharmacology, Faculty of Pharmacy, Marmara University, Istanbul 34854, Turkey.
Ilke KabaogluDepartment of Pharmacology, Faculty of Pharmacy, Marmara University, Istanbul 34854, Turkey.
Ece GulerUCL Division of Surgery and Interventional Science, Royal Free Hospital Campus, University College London, London NW3 2PF, UK.
Manuel Pedro F GraçaI3N and Physics Department, University of Aveiro, Aveiro 3810-193, Portugal.
Oguzhan GunduzCenter for Nanotechnology and Biomaterials Application and Research, Marmara University, Istanbul 34722, Turkey.
Deepak M KalaskarUCL Division of Surgery and Interventional Science, Royal Free Hospital Campus, University College London, London NW3 2PF, UK.
Muhammet Emin CamUCL Division of Surgery and Interventional Science, Royal Free Hospital Campus, University College London, London NW3 2PF, UK.ORCID 0000-0001-5398-6801

Funding

Türkiye Bilimsel ve Teknolojik Araştirma Kurumu 1919B012002428
6 · The paper itself

Abstract

Novel therapeutic strategies are essential for enhancing efficacy and accelerating the treatment of diabetes mellitus. This investigation focused on incorporating empagliflozin into a composite of polylactic acid and polycaprolactone, resulting in the fabrication of drug-loaded fibrous patches (DFPs) for transdermal application, both by electrospinning (ES) and by pressurized gyration (PG). Scanning electron microscopy results revealed that DFPs generated through the PG method exhibited smaller diameters and a larger surface area than ES. Fourier-transform infrared spectroscopy and X-ray powder diffraction analyses confirmed the successful encapsulation of the drug in both DFPs. DFPs/PG exhibited a controlled release of 98.7 ± 1.3% of the total drug over 14 days, while DFPs/ES released 98.1 ± 2.1% in 12 days, according to

Indexed as

Benzhydryl CompoundsFibroblastsGlucosidesPolyestersHumansBenzhydryl CompoundsempagliflozinGlucosidespolycaprolactonePolyesterspoly(lactide)electrospinningempagliflozinpressurized gyrationtransdermaltype 2 diabetes mellitus

Identifiers

PMID40070337
PMCPMC11897825

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.