Evidence map›Paper›PMID 40070172›Full record

ArticleInternational journal of immunopathology and pharmacology

Dissociation between the expression of cGAS/STING and a senescence-associated signature in colon cancer.

Sofian Al Shboul, Ola Abu Al Karsaneh, Moath Alrjoub, Mohammad Al-Qudah, Mohammed El-Sadoni, Ahmad Alhesa, Mohannad Ramadan, Marwa Barukba, Esraa Fares Al-Quran, Amr Masaadeh and 6 more

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Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Sofian Al ShboulDepartment of Pharmacology and Public Health, Faculty of Medicine, The Hashemite University, Zarqa, Jordan.ORCID 0000-0002-0455-4380
Ola Abu Al KarsanehDepartment of Microbiology, Pathology and Forensic Medicine, Faculty of Medicine, The Hashemite University, Zarqa, Jordan.
Moath AlrjoubDepartment of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Mohammad Al-QudahDepartment of Microbiology, Pathology and Forensic Medicine, Faculty of Medicine, The Hashemite University, Zarqa, Jordan.
Mohammed El-SadoniDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman, Jordan.
Ahmad AlhesaDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman, Jordan.
Mohannad RamadanDepartment of Pharmacology and Public Health, Faculty of Medicine, The Hashemite University, Zarqa, Jordan.
Marwa BarukbaDepartment of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Esraa Fares Al-QuranDepartment of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Amr MasaadehDepartment of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Farah N AlmasriDepartment of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Uruk ShahinDepartment of Pharmacology and Public Health, Faculty of Medicine, The Hashemite University, Zarqa, Jordan.
Moureq R AlotaibiDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Mohammad Al-AzabDepartment of Microbiology, Pathology and Forensic Medicine, Faculty of Medicine, The Hashemite University, Zarqa, Jordan.
Ashraf I KhasawnehDepartment of Microbiology, Pathology and Forensic Medicine, Faculty of Medicine, The Hashemite University, Zarqa, Jordan.
Tareq SalehDepartment of Pharmacology and Public Health, Faculty of Medicine, The Hashemite University, Zarqa, Jordan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe effect of the cGAS/STING pathway on antitumor immunity and its connection to senescence in vivo necessitates further investigation.

introductionCellular senescence and its secretory phenotype (the SASP) are implicated in modulating the immune microenvironment of cancer possibly through the cGAS/STING pathway.

methodsGene expression data from paired colon cancer and adjacent non-malignant mucosa (98 patients,

resultsApproximately one-quarter of patients displayed senescence profiles in both gene sets, yet without significantly correlating with cGAS/STING expression. Notably, cGAS expression was higher than STING in tumor tissue compared to non-malignant colonic mucosa. Protein analysis showed 83% positive cGAS expression and 39% positive STING expression, with discrepancies in expression patterns. Additionally, 15% of samples lacked both markers, while 35% exhibited positive staining for both. No significant correlations were found between cGAS/STING status and tumor stage, patient age, lymphovascular invasion, or lymph node involvement.

conclusionsOur findings demonstrate significant senescence marker expression in colorectal cancer samples but with no correlation with cGAS/STING.

Indexed as

Cellular SenescenceColonic NeoplasmsMembrane ProteinsNucleotidyltransferasesAdultAgedAged, 80 and overCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedSTING ProteincGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseMembrane ProteinsNucleotidyltransferasesSTING1 protein, humanSTING ProteincGAScolon cancerSASPsenescenceSTING

Identifiers

PMID40070172
PMCPMC11898089

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.