ReviewCurrent medicinal chemistry2025
Mannich Bases: Promising Scaffolds for the Treatment of Infectious Diseases.
Review in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
Abstract
Mannich bases, synthesized through the reaction of an aldehyde, a primary or secondary amine, and a compound bearing an acidic hydrogen atom, represent a versatile class of scaffolds in medicinal chemistry. This review explores their broad spectrum of biological activities, emphasizing their potential in combating infectious diseases. With demonstrated efficacy against bacteria, fungi, and parasites, Mannich bases stand out as promising candidates for the development of novel therapeutic agents. Their versatility arises from the ability of their electronic, steric, and conformational parameters to modulate receptor interactions, significantly expanding their applicability in drug design. The review provides an in-depth analysis of the structure-activity relationship (SAR) of Mannich bases, highlighting how specific structural modifications enhance their biological activity. Additionally, it examines the lipophilic properties of these compounds, offering key insights into their influence on pharmacokinetics and pharmacodynamics. This understanding is essential for optimizing the development of novel therapeutics, particularly for addressing challenging infectious diseases. By integrating these aspects, this review underscores the pivotal role of Mannich bases in overcoming current challenges in drug resistance and shaping the future of drug discovery and development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.