Evidence map›Paper›PMID 40070064›Full record

ArticleEndocrine, metabolic & immune disorders drug targets2026

Epstein-Barr Virus and Human Papillomavirus Infection in Papillary Thyroid Carcinoma: A Correlation Study

Runyu Zhao, Yingying Lu, Weiqiang Teng, Xiaocheng Xue, Yi Zhang, Shuixian Huang, XIaoping Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine, metabolic & immune disorders drug targets, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Runyu ZhaoPostgraduate Training Base at Shanghai Gongli Hospital, Ningxia Medical University, Shanghai 200135, China.
Yingying LuSchool of Medicine, Shanghai University, Shanghai 200444, China.
Weiqiang TengDepartment of Otolaryngology, First Affiliated Hospital of Soochow University, Suzhou 215000, China.
Xiaocheng XueDepartment of Otolaryngology, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, China.
Yi ZhangDepartment of Otolaryngology, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, China.
Shuixian HuangDepartment of Otolaryngology, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, China.
XIaoping ChenDepartment of Otolaryngology, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study explores the presence and clinical significance of Epstein- Barr Virus (EBV) and Human Papillomavirus (HPV) in papillary thyroid carcinoma (PTC). EBV and HPV are known to contribute to various cancers, but their roles in thyroid cancer development are debated.

methodParaffin-embedded tissue blocks from PTC patients (n=255) who underwent thyroid surgery between 2020 and 2021 were analyzed for EBV and HPV DNA using PCR-based methods.

resultsResults showed EBV positivity in 45.1% of PTC cases, significantly higher than in benign thyroid tumors (35.2%), while HPV positivity was low (0.7%). EBV positivity was not associated with age, gender, lesion type, lymph node metastasis, or extrathyroidal extension but was significantly higher in PTC cases with concurrent Hashimoto's thyroiditis. The study suggests a notable presence of EBV in PTC, especially in cases with Hashimoto's thyroiditis, but indicates a limited role for HPV in thyroid cancer.

conclusionFurther research is warranted to understand the specific pathogenic mechanisms and potential therapeutic implications of EBV and HPV in thyroid cancer.

Indexed as

Epstein-Barr Virus InfectionsHuman Papillomavirus VirusesPapillomavirus InfectionsThyroid Cancer, PapillaryThyroid NeoplasmsAdultAgedFemaleHashimoto DiseaseHerpesvirus 4, HumanHumansMaleMiddle AgedEpstein-Barr VirusHashimoto's thyroiditisHuman Papillomaviruspapillary thyroid carcinoma

Identifiers

PMID40070064
PMCPMC13284635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.