Evidence map›Paper›PMID 40069901›Full record

Trial reportBMC psychology2025

The association between quality of life and psychological flexibility, depressive, anxiety or insomnia symptoms in patients with persistent indoor environment-related symptoms or chronic fatigue.

Sanna Selinheimo, Aki Vuokko, Päivi Lappalainen, Katariina Keinonen, Markku Sainio, Raimo Lappalainen, Tiina Paunio

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04532827 (The Effectiveness of Web-based Rehabilitation for Enhancing Workability and Daily Functioning for Persistent Physical Symptoms.), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04532827 naunknown statusnot on this map

The Effectiveness of Web-based Rehabilitation for Enhancing Workability and Daily Functioning for Persistent Physical Symptoms.

TypeinterventionalSponsorFinnish Institute of Occupational HealthRan2020 to 2023Enrolled105ConditionsPersistent Physical Symptoms, Indoor Environment Associated Symptoms, Indoor Air Associated Symptoms, Chronic Fatigue SyndromeArmsCase formulation with web-program
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sanna SelinheimoFinnish Institute of Occupational Health, Helsinki, Finland. sanna.selinheimo@ttl.fi.ORCID https://orcid.org/0000-0003-0563-9017
Aki VuokkoFinnish Institute of Occupational Health, Helsinki, Finland.ORCID https://orcid.org/0009-0004-8057-3235
Päivi LappalainenDepartment of Psychology, University of Jyväskylä, Jyväskylä, Finland.ORCID https://orcid.org/0000-0001-9038-894X
Katariina KeinonenDepartment of Psychology, University of Jyväskylä, Jyväskylä, Finland.ORCID https://orcid.org/0000-0003-3228-5357
Markku SainioOutpatient Clinic for Functional Disorders, HUS Helsinki University Hospital, Helsinki, Finland.ORCID https://orcid.org/0000-0002-3145-1301
Raimo LappalainenDepartment of Psychology, University of Jyväskylä, Jyväskylä, Finland.ORCID https://orcid.org/0000-0001-6683-134X
Tiina PaunioDepartment of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland.ORCID http://orcid.org/0000-0002-5560-0666

Funding

Social Insurance Institution of Finland 75/331/2019
6 · The paper itself

Abstract

backgroundPersistent physical symptoms (PPS) can significantly impair health-related quality of life (HRQoL) and are often accompanied by psychiatric comorbidity. Psychological flexibility (PF), characterized by the ability to adapt functionally and congruently to diverse situations based on personal values, may play a crucial role in determining HRQoL. This study aims to examine the associations between symptoms of depression, anxiety or insomnia or PF and HRQoL among individuals with PPS associated with (i) the indoor environment (IE), (ii) chronic fatigue, or (iii) both.

methodsWe utilized the baseline data (n = 103) from a randomized controlled trial focused on improving the HRQoL of individuals (mean age 46.1, SD 7.8, 86% women) experiencing PPS associated with IE or chronic fatigue. Self-report questionnaires were administered to evaluate symptoms of depression, anxiety, insomnia, and dimensions of PF, including acceptance, cognitive fusion, and thought suppression. The primary outcome was HRQoL, assessed using a 15D questionnaire. The association between symptoms, PF dimensions, and HRQoL was examined using Pearson's correlation and ANCOVA.

resultsSymptoms of depression, anxiety, and insomnia were negatively associated with HRQoL (p <.001) across all participants. Among individuals with PPS associated with IE, higher PF was significantly associated with higher HRQoL. No association was found between PF and HRQoL in those with chronic fatigue-associated PPS or both conditions.

conclusionsPF associated with positive outcomes in HRQoL in individuals with PPS associated with the indoor environment, but not in those with chronic fatigue. Further research on the differences between these groups is warranted to enhance treatment targeting.

trial registrationClinicaltrials.gov NCT04532827 (registered 26.08.2020).

Indexed as

Adaptation, PsychologicalAnxietyDepressionFatigue Syndrome, ChronicQuality of LifeSleep Initiation and Maintenance DisordersAdultFemaleHumansMaleMiddle AgedChronic fatigueDepressionIndoor environmentPersistent physical symptomsPsychological flexibilityQuality of life

Identifiers

PMID40069901
PMCPMC11900652

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.