Evidence map›Paper›PMID 40069890›Full record

ArticleBMC research notes2025

Reference intervals for CD4 and hemoglobin among apparently healthy pregnant women in Addis Ababa, Ethiopia.

Dinkenesh Chalchisa, Yohannes Belay, Melkitu Kassaw, Endalkachew Befekadu, Letebrhan G/Egzeabher, Gebremedhin Gebremicael, Boki Lengiso, Dawit Chala, Zewdineh Sahlemariam, Estifanos Kebede and 2 more

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Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Dinkenesh ChalchisaNational HIV Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia. dinkeneshc@gmail.com.
Yohannes BelayNational HIV Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Melkitu KassawFood Science and Nutrition Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Endalkachew BefekaduDepartment of Medical Laboratory, Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia.
Letebrhan G/EgzeabherDepartment of Medical Laboratory, Yekatit 12 Medical College Hospital, Addis Ababa, Ethiopia.
Gebremedhin GebremicaelNational HIV Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Boki LengisoNational HIV Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Dawit ChalaNational HIV Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Zewdineh SahlemariamSchool of Medical Laboratory Sciences, Faculty of Medicine, Institute of Health Science, Jimma University, Jimma, Ethiopia.
Estifanos KebedeSchool of Medical Laboratory Sciences, Faculty of Medicine, Institute of Health Science, Jimma University, Jimma, Ethiopia.
Ebba AbateEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Aster TsegayeDepartment of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMost African countries, including Ethiopia, have not developed local well-defined reference intervals (RIs) for immuno-hematological testes in terms of pregnant women. As a result, we were using reference intervals derived from non-Africans. This is not appropriate because CD4 + T cell counts (CD4 count) are affected by several factors including ethnic and environmental factors. Therefore, this study aimed to develop reference interval for CD4 count for apparently healthy pregnant women in Addis Ababa, Ethiopia.

resultsAfter excluding six pregnant women who did not pass the screening tests, 156 apparently healthy pregnant women who were 18-49 years old were included in the final analysis. The medians of CD4 absolute counts and CD4% with inter-quartile ranges [IQR] were 757.5 [611.3-925.5] cells/µL and 43.6% [39.9-47.3] respectively while the median and IQR hemoglobin values were 14.3 g/dL [13.4-15.1]. The respective reference intervals for absolute CD4 cell count and % CD4 were 416.9-1218.4 cells/µL and 32.1-57.3%, respectively. Significant changes were observed in hemoglobin level between trimesters (P < 0.05).

conclusionThe results of this study showed a decrease in both percentage and absolute CD4 + T cell counts when compared to those of non-African and African countries. Establishing local reference values for diverse groups is therefore crucial.

Indexed as

CD4-Positive T-LymphocytesHemoglobinsAdolescentAdultCD4 Lymphocyte CountEthiopiaFemaleHumansMiddle AgedPregnancyReference ValuesYoung AdultHemoglobins%CD4CD4 countEthiopiaHemoglobinReference interval

Identifiers

PMID40069890
PMCPMC11895125

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