Evidence map›Paper›PMID 40069888›Full record

ArticleActa neuropathologica communications2025

Targeting NAD + biosynthesis suppresses TGF-β1/Smads/RAB26 axis and potentiates cisplatin cytotoxicity in non-small cell lung cancer brain metastasis.

Liyun Zhou, Zhiying Li, Shengli Zhou, Bin Wang, Zhen Liang, Sen Hu, Hang Zhang, Lin Duan, Dongxu Zhao, Luyao Cheng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Liyun Zhou *Department of Neurosurgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, People's Republic of China.
Zhiying Li *Department of Neurosurgery, The 7th People's Hospital of Zhengzhou, Zhengzhou, 450000, China.
Shengli Zhou *Department of Pathology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, People's Republic of China.
Bin WangDepartment of Neurosurgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, People's Republic of China.
Zhen LiangDepartment of Neurosurgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, 450008, China.
Sen HuDepartment of Neurosurgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, People's Republic of China.
Hang ZhangDepartment of Neurosurgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, People's Republic of China.
Lin DuanDepartment of Neurosurgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, People's Republic of China.
Dongxu ZhaoDepartment of Neurosurgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, People's Republic of China.
Luyao ChengDepartment of Neurosurgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, People's Republic of China.
Hang RenDepartment of Neurosurgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, People's Republic of China.
Hiroaki WakimotoDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. HWAKIMOTO@mgh.harvard.edu.
Ming LiDepartment of Neurosurgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, People's Republic of China. MINGLI@zzu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nicotinamide adenine dinucleotide (NAD

Indexed as

Antineoplastic AgentsBrain NeoplasmsCarcinoma, Non-Small-Cell LungCisplatinLung NeoplasmsNADAnimalsApoptosisCell Line, TumorCytokinesFemaleHumansMaleMiceMice, NudeNicotinamide PhosphoribosyltransferaseAntineoplastic AgentsCisplatinCytokinesNADNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humanTGFB1 protein, humanTransforming Growth Factor beta1CisplatinNicotinamide adenine dinucleotideNon-small cell lung cancer brain metastasis

Identifiers

PMID40069888
PMCPMC11895195

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.