ArticleBMC pulmonary medicine2025
Association between allergic rhinitis, nasal polyps, chronic sinusitis and chronic respiratory diseases: a mendelian randomization study.
Article in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The Association Between Allergic Rhinitis, Eosinophilic Inflammation, and Postoperative Recurrence in Nasal Polyps.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Article
- Oral health status and esophageal diseases: Univariate and multivariate Mendelian randomization analyses.Medicine · 2026Article
- Diagnostic value and immune microenvironment regulatory network of metabolic reprogramming in chronic rhinosinusitis with nasal polyps identified by multidimensional transcriptome integration and machine learning.Frontiers in immunology · 2026Article
- Development and validation of a nomogram for predicting the efficacy of vidian neurectomy in the treatment of chronic rhinosinusitis with nasal polyps combined with allergic rhinitis.Frontiers in surgery · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpidemiological investigations provide considerable evidence supporting the coexistence of upper airway ailments with lower airway disorders, but the association between common nasal diseases, such as allergic rhinitis, chronic sinusitis, nasal polyps, and chronic respiratory conditions require further exploration.
methodsIn this study, a two-sample mendelian randomization was employed to explore the potential association between allergic rhinitis, nasal polyps, and chronic sinusitis with various chronic respiratory diseases. For the primary analysis, summary statistics related to chronic respiratory diseases were obtained from the UK Biobank of European ancestry. To externally validate the results, summary statistics related to chronic respiratory diseases were sourced from the FinnGen R10 database. The analysis incorporated various methodologies, including the inverse variance weighted method, the MR Egger method, and the weighted median method. Sensitivity analysis encompassed Cochran 's Q test, MR-Egger intercept tests, leave-one-out analyses, and the construction of funnel plots.
resultsAllergic rhinitis was significantly associated with asthma (UKB database, OR 1.082, 95% CI 1.072-1.0924, P < 0.001; FinnGen database, OR 1.382, 95% CI 1.305-1.462, P < 0.001), COPD (UKB database, OR 1.003, 95% CI 1.001-1.006, P = 0.020; FinnGen database, OR 1.102, 95% CI 1.037-1.172, P = 0.002), ILD (UKB database, OR 1.013, 95% CI 1.010-1.017, P < 0.001; FinnGen database, OR 1.152, 95% CI 1.035-1.283, P = 0.010). Nasal polyps were potentially related to the increased risks of COPD (UKB database, OR 1.003, 95% CI 1.001-1.004, P < 0.001; FinnGen database, OR 1.092, 95% CI 1.050-1.136, P < 0.001) and bronchiectasis (UKB database, OR 1.000, 95% CI 1.000-1.001, P = 0.036; FinnGen database, OR 1.109, 95% CI 1.022-1.203, P = 0.013).
conclusionsThis study indicates a potential relationship between allergic rhinitis and respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD), and interstitial lung disease (ILD). Additionally, the presence of nasal polyps appears to be correlated with an increased prevalence of COPD and bronchiectasis.
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