ArticleBMC complementary medicine and therapies2025
Phytochemical analysis, antioxidant activity, and cytotoxic effects of Caulerpa lentillifera extracts inducing cell apoptosis and sub-G/G0-G1 cell cycle arrest in KON oral cancer cells.
Article in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- The anti-leukemic effects of vitamin K4 by modulating the JAK/STAT signaling pathway.Cancer cell international · 2026Article
- GC-MS Profiling, Cytotoxicity and Antiviral Activity of Caulerpa lentillifera and C. macrodisca from Northern Coastal Waters of Borneo Island, Eastern Malaysia.Marine biotechnology (New York, N.Y.) · 2026Article
- Molecular identification and biological activity of a red sea bacterial isolate.BMC microbiology · 2026Article
- Immunostimulant activity of Centella asiatica (ECa 233) on RAW 264.7 macrophages.BMC complementary medicine and therapies · 2026Article
- Therapeutic assessment ofFrontiers in oncology · 2026Article
- Anti-cancer effects of plant extracts in head and neck squamous cell carcinoma.Frontiers in pharmacology · 2026Review
- Carotenoid and peptide supplementation from Caulerpa sp. (sea grapes) extract mitigate metabolic syndrome in cholesterol-enriched diet rats via modulation of gut microbiota.Diabetology & metabolic syndrome · 2025Article
- Cytotoxic and apoptotic effects of novel phytochemical extracts on oral squamous cell carcinoma cells.Bioinformation · 2025Article
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Abstract
backgroundMarine algae have excellent phytoconstituents with notable biological activity and bioactive therapeutic benefits, but the anti-oral cancer activity of Caulerpa lentillifera (C. lentillifera) has not been widely studied. This study aimed to explore the anti-cancer properties of C. lentillifera to gain insights into possible treatment approaches.
methodsThe three C. lentillifera extracts were prepared using the maceration method with methanol (CLM), ethanol (CLE), and acetone (CLA). The chemical composition of extracts of C. lentillifera was investigated. Its metabolite profiles were selectively further investigated using the LC-QTOF MS/MS technique and their antioxidative activity was evaluated. The cytotoxic effect on KON cells and MRC-5 cells was assessed using the MTT test. Morphological changes and apoptosis were examined through Hoechst 33,258 and AO double staining, while DAPI and FDA double labeling were used to observe the nucleus and cytoplasm. Using a flow cytometer, the percentage of cell cycle arrest was calculated and the fraction of cell death was examined.
resultsThe CLA exhibited higher quantities of TPC, TFC, chlorophyll a, and chlorophyll b compared to the CLM and CLE. The LC-QTOF MS/MS analysis revealed ten major phytochemicals in the CLA. The three C. lentillifera extracts exhibited antioxidative activity, with the CLE demonstrating significantly higher antioxidant activity compared to the CLM and CLA. In-vitro, the KON oral cancer cells exhibited sensitivity to CLA, CLE, and CLM in that order. The three extracts induced ROS-mediated cell death as well as disruption of mitochondrial membrane potential, with concentrations at IC
conclusionThe findings showed that C. lentillifera has several functional metabolites, antioxidative activity, and strong anti-tumor properties. According to these results, C. lentillifera extracts may be utilized to treat oral cancer.
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