ArticleBMC biology2025
Integrated functional genomic analysis identifies regulatory variants underlying a major QTL for disease resistance in European sea bass.
Article in BMC biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Bony fish genomes: Status and gaps.Journal of fish biology · 2026Review
- Predicting VNN resistance in European sea bass using machine learning on high dimensional low sample size data.Frontiers in bioinformatics · 2026Article
- Comparative Analysis of CRISPR/Cas9 Delivery Methods in Marine Teleost Cell Lines.International journal of molecular sciences · 2025Article
- Structural variant landscape provides insights into genome organisation and domestication in European seabass.BMC biology · 2025Article
- Deciphering European Sea Bass (International journal of molecular sciences · 2025Article
- Temporal profiling of host transcriptome highlights time- and tissue-dependent Interferon pathway activation in NNV-infected European sea bass.Scientific reports · 2025Article
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Authors and funding
15 authors.
Funding
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Abstract
backgroundViral nervous necrosis (VNN) is an important viral disease threatening global aquaculture sustainability and affecting over 50 farmed and ecologically important fish species. A major QTL for resistance to VNN has been previously detected in European sea bass, but the underlying causal gene(s) and mutation(s) remain unknown. To identify the mechanisms and genetic factors underpinning resistance to VNN in European sea bass, we employed integrative analyses of multiple functional genomics assays in European sea bass.
resultsThe estimated heritability of VNN resistance was high (h
conclusionsThe SNP variant CHR3:10,077,301, through modulation of IFI27L2 and IFI27L2A genes, is likely the causative mutation underlying resistance to VNN in European sea bass. This is one of the first causative mutations discovered for disease resistance traits in fish and paves the way for marker-assisted selection as well as biotechnological approaches to enhance resistance to VNN in European sea bass and other susceptible species.
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